Source:http://linkedlifedata.com/resource/pubmed/id/11129465
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2000-12-20
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| pubmed:abstractText |
Cancerous tumor growth creates cells with abnormal DNA. Allelic-loss experiments identify genomic deletions in cancer cells, but sources of variation and intrinsic dependencies complicate inference about the location and effect of suppressor genes; such genes are the target of these experiments and are thought to be involved in tumor development. We investigate properties of an instability-selection model of allelic-loss data, including likelihood-based parameter estimation and hypothesis testing. By considering a special complete-data case, we derive an approximate calibration method for hypothesis tests of sporadic deletion. Parametric bootstrap and Bayesian computations are also developed. Data from three allelic-loss studies are reanalyzed to illustrate the methods.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:month |
Dec
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| pubmed:issn |
0006-341X
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
56
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1088-97
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:11129465-Adenocarcinoma,
pubmed-meshheading:11129465-Adenocarcinoma, Follicular,
pubmed-meshheading:11129465-Alleles,
pubmed-meshheading:11129465-Bayes Theorem,
pubmed-meshheading:11129465-Biometry,
pubmed-meshheading:11129465-Chromosome Deletion,
pubmed-meshheading:11129465-Gene Deletion,
pubmed-meshheading:11129465-Genes, Tumor Suppressor,
pubmed-meshheading:11129465-Humans,
pubmed-meshheading:11129465-Likelihood Functions,
pubmed-meshheading:11129465-Lod Score,
pubmed-meshheading:11129465-Loss of Heterozygosity,
pubmed-meshheading:11129465-Male,
pubmed-meshheading:11129465-Markov Chains,
pubmed-meshheading:11129465-Models, Statistical,
pubmed-meshheading:11129465-Neoplasms,
pubmed-meshheading:11129465-Prostatic Neoplasms,
pubmed-meshheading:11129465-Thyroid Neoplasms
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| pubmed:year |
2000
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| pubmed:articleTitle |
Inferring the location and effect of tumor suppressor genes by instability-selection modeling of allelic-loss data.
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| pubmed:affiliation |
Department of Statistics, University of Wisconsin-Madison, 1210 West Dayton Street, Madison, Wisconsin 53706-1685, USA. newton@stat.wisc.edu
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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