Source:http://linkedlifedata.com/resource/pubmed/id/11129184
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
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| pubmed:dateCreated |
2000-12-20
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| pubmed:abstractText |
Currently, there is no reliable reconstructive modality allowing anatomic resurfacing of traumatic digital osteochondral articular defects. The purpose of the present study is to demonstrate the utility of Medpor, a high-density porous polyethylene (HDPP) scaffold biomaterial that can (1) be readily contoured to fit any joint defect, (2) permit stable internal fixation, and (3) permit osteocyte and chondrocyte ingrowth and subsequent articular cartilage resurfacing necessary to restore joint congruity. HDPP has gained wide acceptance for use in craniofacial and skeletal reconstruction and augmentation. An avian non-weight-bearing joint model was designed to study the role of the HDPP implant in small joint reconstruction. An osteochondral defect was created with a 5-mm circular punch in the humeral articular surface of both glenohumeral joints of 32 adult White Leghorn chickens. In each animal, one defect was press-fitted with a correspondingly sized HDPP implant (HDPP implant group); the contralateral defect was filled with the original osteochondral plug (isograft group) or left unrepaired (control group). At 2 weeks, and 1, 3, and 6 months,joints from each group were harvested and evaluated. Over the 6-month study period, joints in the control group demonstrated healing with dense collagenous scar tissue leaving residual defects at the articular surfaces and significant degenerative disease of the glenohumeral joints radiographically. Joints in the isograft group demonstrated near-complete resorption with some preservation of the cartilaginous cap but overall depression of the articular surface and significant degenerative joint disease. Joints in the HDPP implant group demonstrated stable fixation by highly mineralized bony trabecular ingrowth, preservation of the articular contour of the humeral head, and no evidence of significant degenerative joint disease. These findings indicate a potential role for this high-density porous polyethylene implant in the reconstruction of small joint articular and osseous defects.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
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| pubmed:issn |
0032-1052
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
106
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1547-54
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| pubmed:dateRevised |
2011-2-16
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| pubmed:meshHeading |
pubmed-meshheading:11129184-Animals,
pubmed-meshheading:11129184-Arthroplasty, Replacement,
pubmed-meshheading:11129184-Biocompatible Materials,
pubmed-meshheading:11129184-Bone Resorption,
pubmed-meshheading:11129184-Bone Transplantation,
pubmed-meshheading:11129184-Cartilage,
pubmed-meshheading:11129184-Cartilage, Articular,
pubmed-meshheading:11129184-Chickens,
pubmed-meshheading:11129184-Chondrocytes,
pubmed-meshheading:11129184-Cicatrix,
pubmed-meshheading:11129184-Collagen,
pubmed-meshheading:11129184-Follow-Up Studies,
pubmed-meshheading:11129184-Humerus,
pubmed-meshheading:11129184-Joints,
pubmed-meshheading:11129184-Models, Animal,
pubmed-meshheading:11129184-Osteoarthritis,
pubmed-meshheading:11129184-Osteocytes,
pubmed-meshheading:11129184-Osteogenesis,
pubmed-meshheading:11129184-Polyethylenes,
pubmed-meshheading:11129184-Prostheses and Implants,
pubmed-meshheading:11129184-Prosthesis Design,
pubmed-meshheading:11129184-Shoulder,
pubmed-meshheading:11129184-Surface Properties,
pubmed-meshheading:11129184-Transplantation, Isogeneic
|
| pubmed:year |
2000
|
| pubmed:articleTitle |
Osteochondral reconstruction of a non-weight-bearing joint using a high-density porous polyethylene implant.
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| pubmed:affiliation |
Department of Plastic Surgery, Brown University School of Medicine, Rhode Island Hospital, Providence 02905, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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