11128638

Source:http://linkedlifedata.com/resource/pubmed/id/11128638

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0162714
pubmed:issue	23
pubmed:dateCreated	2000-12-20
pubmed:abstractText	HIV protease inhibitors containing 6-hydroxy-1,3-dioxin-4-one ring system as a new scaffold have been prepared. Among them, compound 4d showed potent HIV protease inhibitory activity (IC50 = 0.01 microM) and antiviral activity in cell culture (EC50 = 0.96 microM, SI = 65.69).
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Anti-HIV Agents, http://linkedlifedata.com/resource/pubmed/chemical/Dioxins, http://linkedlifedata.com/resource/pubmed/chemical/HIV Protease Inhibitors
pubmed:status	MEDLINE
pubmed:month	Dec
pubmed:issn	0960-894X
pubmed:author	pubmed-author:KimS NSN, pubmed-author:LeeC KCK, pubmed-author:LeeJ YJY, pubmed-author:LeeY SYS, pubmed-author:ParkHH
pubmed:issnType	Print
pubmed:day	4
pubmed:volume	10
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	2625-7
pubmed:dateRevised	2006-11-15
pubmed:meshHeading	pubmed-meshheading:11128638-Anti-HIV Agents, pubmed-meshheading:11128638-Cells, Cultured, pubmed-meshheading:11128638-Dioxins, pubmed-meshheading:11128638-HIV Protease Inhibitors, pubmed-meshheading:11128638-Magnetic Resonance Spectroscopy, pubmed-meshheading:11128638-Microbial Sensitivity Tests
pubmed:year	2000
pubmed:articleTitle	6-Hydroxy-1,3-dioxin-4-ones as non-peptidic HIV protease inhibitors.
pubmed:affiliation	Division of Life Sciences, Korea Institute of Science & Technology, Cheongryang, Seoul, South Korea.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't