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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1403
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pubmed:dateCreated |
2000-12-20
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pubmed:abstractText |
An approximate expression for the probability distribution of the age of a neutral allele as a function of its frequency is derived for a population undergoing arbitrary changes in population size. A simple maximum-likelihood estimator of allele age based on frequency is also obtained. The distribution of allele age, combined with a model predicting the extent of intra-allelic variability generated by mutation and recombination, leads to a statistical test of whether a rare allele has experienced natural selection. The test is based on finding whether there is too little or too much intra-allelic variability to be consistent with the observed frequency. The test is applied to the locus, BRCA1, associated with early-onset breast cancer in humans and shows that two common disease-associated alleles (5382insC and 185delAG) appear to have been subject to natural selection.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11127913-1013904,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11127913-10545460,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11127913-11701630,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11127913-1969843,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11127913-4407212,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11127913-4417585,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11127913-4762875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11127913-6505980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11127913-7719342,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11127913-7920636,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11127913-8013910,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11127913-803010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11127913-8571953,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11127913-9012419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11127913-9463316,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11127913-9585595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11127913-9917213,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11127913-9928476
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0962-8436
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
29
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pubmed:volume |
355
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1663-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
2000
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pubmed:articleTitle |
Allele age and a test for selection on rare alleles.
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pubmed:affiliation |
Department of lntegrative Biology, University of California, Berkeley 94720-3140, USA. slatkin@socrates.berkeley.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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