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rdf:type |
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lifeskim:mentions |
umls-concept:C0004561,
umls-concept:C0005953,
umls-concept:C0597357,
umls-concept:C0871261,
umls-concept:C1517162,
umls-concept:C1704632,
umls-concept:C1705241,
umls-concept:C1705242,
umls-concept:C1706817,
umls-concept:C1706853,
umls-concept:C1709634,
umls-concept:C1879748,
umls-concept:C2911692
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pubmed:dateCreated |
2000-12-26
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pubmed:abstractText |
The expression of different sets of immunoglobulin specificities by fetal and adult B lymphocytes is a longstanding puzzle in immunology. In the past few years it has become clear that production of mu heavy chain and subsequent assembly with surrogate light chain to form the pre-B cell receptor complex is critical to promote development of adult B cell precursors in mouse bone marrow. Recently we found that instead of promoting pre-B cell expansion as in adult bone marrow, this complex inhibits pre-B cell growth in fetal liver, providing a previously unrecognized mechanism for alteration of the B cell repertoire with age. The consequence is very distinct primary repertoires for development of fetal B1 cells and adult bone marrow B2 cells.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0070-217X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
252
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
25-30
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11125482-Adult,
pubmed-meshheading:11125482-Animals,
pubmed-meshheading:11125482-Antibody Specificity,
pubmed-meshheading:11125482-B-Lymphocyte Subsets,
pubmed-meshheading:11125482-Bone Marrow,
pubmed-meshheading:11125482-Cell Lineage,
pubmed-meshheading:11125482-Gene Rearrangement, B-Lymphocyte,
pubmed-meshheading:11125482-Gene Rearrangement, B-Lymphocyte, Heavy Chain,
pubmed-meshheading:11125482-Genes, Immunoglobulin,
pubmed-meshheading:11125482-Hematopoiesis, Extramedullary,
pubmed-meshheading:11125482-Hematopoietic Stem Cells,
pubmed-meshheading:11125482-Humans,
pubmed-meshheading:11125482-Immune System,
pubmed-meshheading:11125482-Immunoglobulin Variable Region,
pubmed-meshheading:11125482-Immunoglobulin mu-Chains,
pubmed-meshheading:11125482-Liver,
pubmed-meshheading:11125482-Mice,
pubmed-meshheading:11125482-Mice, Transgenic,
pubmed-meshheading:11125482-Receptors, Antigen, B-Cell,
pubmed-meshheading:11125482-Recombinant Fusion Proteins,
pubmed-meshheading:11125482-Transfection
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pubmed:year |
2000
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pubmed:articleTitle |
Response by B cell precursors to pre-B receptor assembly: differences between fetal liver and bone marrow.
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pubmed:affiliation |
Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111, USA. rr_hardy@fccc.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Review
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