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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2001-1-12
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pubmed:abstractText |
Vitamin D (calcitriol) has significant antiproliferative effects on various tumor cells in vitro and in vivo. In the clinical situation a major impediment to systemic administration of calcitriol is the side effect of hypercalcemia. To test the potential usefulness of calcitriol for bladder cancer treatment, we studied the antiproliferative effect of vitamin D on 2 human bladder cancer cell lines, 253j and T-24, in vitro. We also examined the in vivo effects of calcitriol in an animal model of bladder cancer using intravesical administration to avoid the toxicity of systemic calcitriol therapy.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-5347
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pubmed:author |
pubmed-author:DhirRR,
pubmed-author:GetzenbergR HRH,
pubmed-author:HershbergerPP,
pubmed-author:JohnsonC SCS,
pubmed-author:KonetyB RBR,
pubmed-author:LavelleJ PJP,
pubmed-author:MeyersS ASA,
pubmed-author:NguyenT STS,
pubmed-author:PirtskalaishviliGG,
pubmed-author:ShurinM RMR,
pubmed-author:TrumpD LDL,
pubmed-author:ZeidelM LML
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pubmed:issnType |
Print
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pubmed:volume |
165
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
253-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11125420-Administration, Intravesical,
pubmed-meshheading:11125420-Animals,
pubmed-meshheading:11125420-Apoptosis,
pubmed-meshheading:11125420-Calcitriol,
pubmed-meshheading:11125420-Carcinoma, Transitional Cell,
pubmed-meshheading:11125420-Cell Division,
pubmed-meshheading:11125420-Cell Line,
pubmed-meshheading:11125420-Female,
pubmed-meshheading:11125420-Humans,
pubmed-meshheading:11125420-Rats,
pubmed-meshheading:11125420-Rats, Inbred F344,
pubmed-meshheading:11125420-Receptors, Calcitriol,
pubmed-meshheading:11125420-Tumor Cells, Cultured,
pubmed-meshheading:11125420-Urinary Bladder Neoplasms
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pubmed:year |
2001
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pubmed:articleTitle |
Effects of vitamin D (calcitriol) on transitional cell carcinoma of the bladder in vitro and in vivo.
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pubmed:affiliation |
Departments of Urology, Surgery, Medicine, Pathology and Pharmacology, University of Pittsburgh Cancer Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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