Linked Life Data

11125147

Source:http://linkedlifedata.com/resource/pubmed/id/11125147

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5500
pubmed:dateCreated
2000-12-28
pubmed:abstractText
The TATA-binding protein (TBP) is believed to function as a key component of the general transcription machinery. We tested the role of TBP during the onset of embryonic transcription by antisense oligonucleotide-mediated turnover of maternal TBP messenger RNA. Embryos without detectable TBP initiated gastrulation but died before completing gastrulation. The expression of many genes transcribed by RNA polymerase II and III was reduced; however, some genes were transcribed with an efficiency identical to that of TBP-containing embryos. Using a similar antisense strategy, we found that the TBP-like factor TLF/TRF2 is essential for development past the mid-blastula stage. Because TBP and a TLF factor play complementary roles in embryonic development, our results indicate that although similar mechanistic roles exist in common, TBP and TLF function differentially to control transcription of specific genes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0036-8075
pubmed:author
pubmed:issnType
Print
pubmed:day
22
pubmed:volume
290
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2312-5
pubmed:dateRevised
2007-3-19
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Distinct roles for TBP and TBP-like factor in early embryonic gene transcription in Xenopus.
pubmed:affiliation
Laboratory for Molecular Embryology, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA. VeenstrG@exchange.nih.gov
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.