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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5500
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pubmed:dateCreated |
2000-12-28
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pubmed:abstractText |
Plasma Abeta42 (amyloid beta42 peptide) is invariably elevated in early-onset familial Alzheimer's disease (AD), and it is also increased in the first-degree relatives of patients with typical late-onset AD (LOAD). To detect LOAD loci that increase Abeta42, we used plasma Abeta42 as a surrogate trait and performed linkage analysis on extended AD pedigrees identified through a LOAD patient with extremely high plasma Abeta. Here, we report linkage to chromosome 10 with a maximal lod score of 3.93 at 81 centimorgans close to D10S1225. Remarkably, linkage to the same region was obtained independently in a genome-wide screen of LOAD sibling pairs. These results provide strong evidence for a novel LOAD locus on chromosome 10 that acts to increase Abeta.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
22
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pubmed:volume |
290
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2303-4
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:11125143-Adult,
pubmed-meshheading:11125143-Age of Onset,
pubmed-meshheading:11125143-Aged,
pubmed-meshheading:11125143-Aged, 80 and over,
pubmed-meshheading:11125143-Alzheimer Disease,
pubmed-meshheading:11125143-Amyloid beta-Peptides,
pubmed-meshheading:11125143-Chromosomes, Human, Pair 10,
pubmed-meshheading:11125143-Female,
pubmed-meshheading:11125143-Genetic Linkage,
pubmed-meshheading:11125143-Genetic Markers,
pubmed-meshheading:11125143-Genetic Predisposition to Disease,
pubmed-meshheading:11125143-Humans,
pubmed-meshheading:11125143-Lod Score,
pubmed-meshheading:11125143-Male,
pubmed-meshheading:11125143-Middle Aged,
pubmed-meshheading:11125143-Pedigree,
pubmed-meshheading:11125143-Peptide Fragments,
pubmed-meshheading:11125143-Phenotype,
pubmed-meshheading:11125143-Quantitative Trait, Heritable
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pubmed:year |
2000
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pubmed:articleTitle |
Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees.
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pubmed:affiliation |
Mayo Clinic Jacksonville, Jacksonville, FL 32224, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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