Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3-4
pubmed:dateCreated
2001-1-23
pubmed:abstractText
As the result of the EUROIMAGE Consortium sequencing project, we have isolated and characterized a novel gene on chromosome 15, TM6SF1. It encodes a 370 amino acid product with enhanced expression in spleen, testis and peripheral blood leukocytes. We have identified another gene, paralogous to TM6SF1 on chromosome 19p12, TM6SF2, with an overall similarity of 68% and 52% identity at the protein level. This conservation has led us to uncover a series of eleven genes in 19p13.3-->p12 with close homology to genes in 15q24--> q26. The percentage of sequence similarity between each paralogous pair of genes at the protein level ranges between 43 and 89%. A partial conservation of synteny with mouse chromosomes 7, 8 and 9 is also observed. The corresponding orthologous genes in mouse of human TM6SF1 and TM6SF2 show a high degree of amino acid sequence conservation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0301-0171
pubmed:author
pubmed:copyrightInfo
Copyright 2000 S. Karger AG, Basel.
pubmed:issnType
Print
pubmed:volume
90
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
255-60
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:11124529-Amino Acid Sequence, pubmed-meshheading:11124529-Animals, pubmed-meshheading:11124529-Base Sequence, pubmed-meshheading:11124529-Chromosomes, Human, Pair 15, pubmed-meshheading:11124529-Chromosomes, Human, Pair 19, pubmed-meshheading:11124529-Cloning, Molecular, pubmed-meshheading:11124529-Conserved Sequence, pubmed-meshheading:11124529-Exons, pubmed-meshheading:11124529-Expressed Sequence Tags, pubmed-meshheading:11124529-Genes, Duplicate, pubmed-meshheading:11124529-Humans, pubmed-meshheading:11124529-Introns, pubmed-meshheading:11124529-Membrane Proteins, pubmed-meshheading:11124529-Mice, pubmed-meshheading:11124529-Molecular Sequence Data, pubmed-meshheading:11124529-Molecular Weight, pubmed-meshheading:11124529-Multigene Family, pubmed-meshheading:11124529-Open Reading Frames, pubmed-meshheading:11124529-Physical Chromosome Mapping, pubmed-meshheading:11124529-Proteins, pubmed-meshheading:11124529-RNA, Messenger, pubmed-meshheading:11124529-RNA Splice Sites, pubmed-meshheading:11124529-Sequence Alignment, pubmed-meshheading:11124529-Sequence Homology, Amino Acid
pubmed:year
2000
pubmed:articleTitle
Cloning of the novel gene TM6SF1 reveals conservation of clusters of paralogous genes between human chromosomes 15q24-->q26 and 19p13.3-->p12.
pubmed:affiliation
Medical and Molecular Genetics Center, Institut de Recerca Oncològica, Hospital Duran i Reynals, L'Hospitalet de Llobregat, Barcelona, Spain.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't