| pubmed-article:11123329 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11123329 | lifeskim:mentions | umls-concept:C0023270 | lld:lifeskim |
| pubmed-article:11123329 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:11123329 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:11123329 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:11123329 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:11123329 | lifeskim:mentions | umls-concept:C0599958 | lld:lifeskim |
| pubmed-article:11123329 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:11123329 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:11123329 | pubmed:dateCreated | 2001-1-3 | lld:pubmed |
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| pubmed-article:11123329 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11123329 | pubmed:abstractText | Persistent immunity against Leishmania: infections in humans is mediated predominantly by CD4(+) T cells of the Th1 phenotype. Herein we report the expression cloning of eight Leishmania: Ags using parasite-specific T cell lines derived from an immune donor. The Ags identified by this technique include the flagellar proteins alpha- and beta-tubulin, histone H2b, ribosomal protein S4, malate dehydrogenase, and elongation factor 2, as well as two novel parasite proteins. None of these proteins have been previously reported as T cell-stimulating Ags from Leishmania: beta-tubulin-specific T cell clones generated against Leishmania: major amastigotes responded to Leishmania:-infected macrophages and dendritic cells. IFN-gamma enzyme-linked immunospot analysis demonstrated the presence of T cells specific for several of these Ags in PBMC from self-healing cutaneous leishmaniasis patients infected with either Leishmania: tropica or L. major. The responses elicited by Leishmania: histone H2b were particularly striking in terms of frequency of histone-specific T cells in PBMC (1 T cell of 6000 PBMC) as well as the percentage of responding donors (86%, 6 of 7). Ags identified by T cells from immune donors might constitute potential vaccine candidates for leishmaniasis. | lld:pubmed |
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| pubmed-article:11123329 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11123329 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11123329 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:11123329 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11123329 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11123329 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11123329 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11123329 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:11123329 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:11123329 | pubmed:author | pubmed-author:ProbstPP | lld:pubmed |
| pubmed-article:11123329 | pubmed:author | pubmed-author:GhalibH WHW | lld:pubmed |
| pubmed-article:11123329 | pubmed:author | pubmed-author:ReedS GSG | lld:pubmed |
| pubmed-article:11123329 | pubmed:author | pubmed-author:WebbJ RJR | lld:pubmed |
| pubmed-article:11123329 | pubmed:author | pubmed-author:MozelMM | lld:pubmed |
| pubmed-article:11123329 | pubmed:author | pubmed-author:BadaroRR | lld:pubmed |
| pubmed-article:11123329 | pubmed:author | pubmed-author:StrombergEE | lld:pubmed |
| pubmed-article:11123329 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11123329 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:11123329 | pubmed:volume | 166 | lld:pubmed |
| pubmed-article:11123329 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11123329 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11123329 | pubmed:pagination | 498-505 | lld:pubmed |
| pubmed-article:11123329 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:11123329 | pubmed:meshHeading | pubmed-meshheading:11123329... | lld:pubmed |
| pubmed-article:11123329 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11123329 | pubmed:articleTitle | Identification and characterization of T cell-stimulating antigens from Leishmania by CD4 T cell expression cloning. | lld:pubmed |
| pubmed-article:11123329 | pubmed:affiliation | Corixa Corporation, Seattle, WA 98104, USA. jwebb@uottawa.ca | lld:pubmed |
| pubmed-article:11123329 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11123329 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11123329 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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