Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2001-2-2
pubmed:abstractText
The present study was designed to determine the effects of melatonin on coronary vasomotor tone. Porcine coronary arteries were suspended in organ chambers for isometric tension recording. Melatonin (10(-10)-10(-5) M) itself caused neither contraction nor relaxation of the tissues. Serotonin (10(-9)-10(-5) M) caused concentration-dependent contractions of coronary arteries, and in the presence of melatonin (10(-7) M) the maximal response to serotonin was increased in rings with but not without endothelium. In contrast, melatonin had no effect on contractions produced by the thromboxane A(2) analog U-46619 (10(-10)-10(-7) M). The melatonin-receptor antagonist S-20928 (10(-6) M) abolished the potentiating effect of melatonin on serotonin-induced contractions in endothelium-intact coronary arteries, as did treatment with 1H-[1, 2,4]oxadiazolo[4,3-a]quinoxalin-1-one (10(-5) M), methylene blue (10(-5) M), or N(G)-nitro-L-arginine (3 x 10(-5) M). In tissues contracted with U-46619, serotonin caused endothelium-dependent relaxations that were inhibited by melatonin (10(-7) M). Melatonin also inhibited coronary artery relaxation induced by sodium nitroprusside (10(-9)-10(-5) M) but not by isoproterenol (10(-9)-10(-5) M). These results support the hypothesis that melatonin, by inhibiting the action of nitric oxide on coronary vascular smooth muscle, selectively potentiates the vasoconstrictor response to serotonin in coronary arteries with endothelium.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/15-Hydroxy-11 alpha,9..., http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Isoproterenol, http://linkedlifedata.com/resource/pubmed/chemical/Melatonin, http://linkedlifedata.com/resource/pubmed/chemical/N-(2-(1-naphthalenyl)ethyl)cyclobuta..., http://linkedlifedata.com/resource/pubmed/chemical/Naphthalenes, http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Donors, http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase, http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type III, http://linkedlifedata.com/resource/pubmed/chemical/Nitroprusside, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytoplasmic and Nuclear, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Melatonin, http://linkedlifedata.com/resource/pubmed/chemical/Serotonin, http://linkedlifedata.com/resource/pubmed/chemical/Vasoconstrictor Agents, http://linkedlifedata.com/resource/pubmed/chemical/Vasodilator Agents, http://linkedlifedata.com/resource/pubmed/chemical/omega-N-Methylarginine
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0363-6135
pubmed:author
pubmed:issnType
Print
pubmed:volume
280
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
H76-82
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:11123220-15-Hydroxy-11 alpha,9..., pubmed-meshheading:11123220-Animals, pubmed-meshheading:11123220-Coronary Vessels, pubmed-meshheading:11123220-Drug Synergism, pubmed-meshheading:11123220-Enzyme Inhibitors, pubmed-meshheading:11123220-Isoproterenol, pubmed-meshheading:11123220-Melatonin, pubmed-meshheading:11123220-Muscle, Smooth, Vascular, pubmed-meshheading:11123220-Muscle Contraction, pubmed-meshheading:11123220-Naphthalenes, pubmed-meshheading:11123220-Nitric Oxide Donors, pubmed-meshheading:11123220-Nitric Oxide Synthase, pubmed-meshheading:11123220-Nitric Oxide Synthase Type III, pubmed-meshheading:11123220-Nitroprusside, pubmed-meshheading:11123220-Receptors, Cell Surface, pubmed-meshheading:11123220-Receptors, Cytoplasmic and Nuclear, pubmed-meshheading:11123220-Receptors, Melatonin, pubmed-meshheading:11123220-Serotonin, pubmed-meshheading:11123220-Swine, pubmed-meshheading:11123220-Vasoconstrictor Agents, pubmed-meshheading:11123220-Vasodilator Agents, pubmed-meshheading:11123220-omega-N-Methylarginine
pubmed:year
2001
pubmed:articleTitle
Melatonin potentiates contractile responses to serotonin in isolated porcine coronary arteries.
pubmed:affiliation
Department of Pharmaceutical Sciences, North Dakota State University, Fargo, North Dakota 58105, USA.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't