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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2001-1-26
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pubmed:abstractText |
We investigated alpha-adrenoceptor-mediated positive chronotropic action in children using a pharmacological autonomic function test. Under cardiac vagal and sympathetic blockade, chronotropic responses to intravenous infusion of an alpha-agonist, phenylephrine, were determined in 129 patients with suspected autonomic dysfunction. Heart rate changes to phenylephrine infusion (0.4 microg/kg/min) for 5 minutes ranged from -2 to 50 beats/min (mean +/- SD, 13.8 +/- 9.7 beats/min). alpha-Adrenoceptor-mediated chronotropic (APC) action more than 5 beats/min was observed in 88 (68%) subjects. APC was negatively correlated with age. Multivariate analysis showed that APC was correlated negatively with beta-sympathetic tone and positively correlated with intrinsic heart rate. These results suggest that the alpha-adrenoceptor-mediated chronotropic action is a developmental phenomenon and may play an important role in controlling heart rate in response to cardiac sympathetic activation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0172-0643
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
40-3
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pubmed:dateRevised |
2008-2-20
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pubmed:meshHeading |
pubmed-meshheading:11123125-Adolescent,
pubmed-meshheading:11123125-Adrenergic alpha-Agonists,
pubmed-meshheading:11123125-Adrenergic alpha-Antagonists,
pubmed-meshheading:11123125-Atropine,
pubmed-meshheading:11123125-Autonomic Nervous System Diseases,
pubmed-meshheading:11123125-Child,
pubmed-meshheading:11123125-Child, Preschool,
pubmed-meshheading:11123125-Female,
pubmed-meshheading:11123125-Heart Rate,
pubmed-meshheading:11123125-Humans,
pubmed-meshheading:11123125-Isoproterenol,
pubmed-meshheading:11123125-Male,
pubmed-meshheading:11123125-Multivariate Analysis,
pubmed-meshheading:11123125-Myocardial Contraction,
pubmed-meshheading:11123125-Phentolamine,
pubmed-meshheading:11123125-Phenylephrine,
pubmed-meshheading:11123125-Propranolol,
pubmed-meshheading:11123125-Receptors, Adrenergic, alpha,
pubmed-meshheading:11123125-Regression Analysis,
pubmed-meshheading:11123125-Syncope
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pubmed:articleTitle |
Evidence of alpha-adrenoceptor-mediated chronotropic action in children.
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pubmed:affiliation |
Department of Pediatrics, Osaka Medical College, 2-7, Daigakucho, Takatsuki-shi, Osaka, Japan 569.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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