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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2000-12-26
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pubmed:abstractText |
This study was designed to compare the degree of lymphocyte apoptosis and Fas-Fas ligand (FasL) expression in AIDS patients and long-term non-progressors (LTNPs) and correlate these parameters with apoptosis-associated perturbations in lymphocyte function. LTNPs had a lower frequency of apoptotic CD4+ and CD8+ T cells compared with subjects with AIDS. This correlated with a lower frequency of cells expressing Fas and FasL. The frequency of selected lymphocyte populations exhibiting a disrupted mitochondrial transmembrane potential (DeltaPsim) and increased superoxide generation was lower in LTNPs than in patients with AIDS; these abnormalities were associated with lower levels of caspase-1 activation in LTNPs. The results indicate a significantly reduced level of apoptosis and apoptosis-associated parameters in LTNPs than in patients developing AIDS. Based on these findings, a crucial role for mitochondria can be predicted in the process of lymphocyte apoptosis during the evolution of AIDS.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11122242-10051507,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11122242-10416520,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11122242-10594560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11122242-10608752,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11122242-10620603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11122242-14731430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11122242-1710634,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11122242-1737061,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11122242-2065663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11122242-2269275,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11122242-6422024,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11122242-6534410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11122242-7503812,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11122242-7523573,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11122242-7536620,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11122242-7536900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11122242-7536901,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11122242-7539037,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11122242-7629499,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11122242-7722446,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11122242-7790370,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11122242-7808485,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11122242-7808486,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11122242-7859743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11122242-8024680,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11122242-8089170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11122242-8098552,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11122242-8157993,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11122242-8288627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11122242-8614469,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11122242-8617980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11122242-8652808,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11122242-8780823,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11122242-8781503,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11122242-8834875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11122242-8846779,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11122242-8924258,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11122242-9007205,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11122242-9018974,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11122242-9028959,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11122242-9237618,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11122242-9467750,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11122242-9573019,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11122242-9583599,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11122242-9728534
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0009-9104
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
122
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
364-73
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:11122242-Humans,
pubmed-meshheading:11122242-Female,
pubmed-meshheading:11122242-Male,
pubmed-meshheading:11122242-Reactive Oxygen Species,
pubmed-meshheading:11122242-Adult,
pubmed-meshheading:11122242-Mitochondria,
pubmed-meshheading:11122242-Membrane Potentials,
pubmed-meshheading:11122242-Cells, Cultured,
pubmed-meshheading:11122242-Leukocytes, Mononuclear,
pubmed-meshheading:11122242-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:11122242-Apoptosis,
pubmed-meshheading:11122242-Membrane Glycoproteins,
pubmed-meshheading:11122242-CD4-Positive T-Lymphocytes,
pubmed-meshheading:11122242-CD8-Positive T-Lymphocytes,
pubmed-meshheading:11122242-Antigens, CD95,
pubmed-meshheading:11122242-Fas Ligand Protein,
pubmed-meshheading:11122242-HIV Long-Term Survivors
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