Source:http://linkedlifedata.com/resource/pubmed/id/11122219
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
12
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pubmed:dateCreated |
2001-1-16
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pubmed:abstractText |
In a recent placebo-controlled study we demonstrated that capsaicin is an efficacious substance in the treatment of non-allergic non-infectious rhinitis. In this study the therapeutic effect lasted more than 9 months. This effect was not based on modulation of inflammation. To evaluate the effect of repeated application of capsaicin to patients with a nasal allergy to house dust mites (HDM), using the same treatment protocol as recently introduced in the treatment of non-allergic patients. Twenty-six patients with rhinitis, 15 females and 11 males (range: 20-46 years; mean 30.5), allergic to HDM were treated with either capsaicin or placebo in a double-blind, placebo-controlled, parallel group design. Nasal reactivity to HDM expressed as nasal symptoms, albumin and leukotriene levels in nasal lavage fluid and responsiveness to histamine, assessed as symptoms before and 6 weeks after treatment, were used to compare both treatment groups. In addition, visual analogue scales and rhinitis quality of life (RQL) assessment before, 6 weeks after and 3 months after treatment were used as outcome variables. No significant effect of capsaicin on nasal challenge tests with HDM (nasal symptoms, albumin and leukotriene levels), on VAS or RQL outcome 6 weeks or 3 month's after treatment, was demonstrated. Capsaicin did have a small effect on the area of the curve (AUC) of histamine dose response curves (P = 0.03). Desensitization with capsaicin in doses sufficient to control symptoms in patients with severe non-allergic rhinitis is lacking therapeutic effect in perennial allergic rhinitis.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0954-7894
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1792-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11122219-Administration, Inhalation,
pubmed-meshheading:11122219-Adult,
pubmed-meshheading:11122219-Allergens,
pubmed-meshheading:11122219-Animals,
pubmed-meshheading:11122219-Capsaicin,
pubmed-meshheading:11122219-Double-Blind Method,
pubmed-meshheading:11122219-Dust,
pubmed-meshheading:11122219-Female,
pubmed-meshheading:11122219-Humans,
pubmed-meshheading:11122219-Male,
pubmed-meshheading:11122219-Middle Aged,
pubmed-meshheading:11122219-Mites,
pubmed-meshheading:11122219-Quality of Life,
pubmed-meshheading:11122219-Questionnaires,
pubmed-meshheading:11122219-Rhinitis, Allergic, Perennial
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pubmed:year |
2000
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pubmed:articleTitle |
Intranasal capsaicin is lacking therapeutic effect in perennial allergic rhinitis to house dust mite. A placebo-controlled study.
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pubmed:affiliation |
Department of Allergology, Institute of Pharmacology, University Hospital Rotterdam & Erasmus University Rotterdam, The Netherlands.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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