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pubmed:abstractText |
Calcitonin gene-related peptides (alpha and beta isoforms), better known as CGRPalpha and CGRPbeta, were isolated twenty years ago. In fact, these were the first peptides to be characterized using a molecular cloning strategy, which is not the traditional approach of biochemical extraction and purification. Paradoxically, progress in the characterization of CGRP receptor subtypes has been extremely slow as a result of difficulties in their cloning and the lack of selective receptor subtype agonists and antagonists. However, exciting progress has been made overthe pasttwo years and is briefly reviewed here.
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pubmed:affiliation |
Douglas Hospital Research Centre and Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, Quebec, Canada. juachr@douglas.mcgill.ca
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