Endothelin (ET)-l is a bronchoconstrictor peptide produced in the airways. It has been implicated in the pathogenesis of asthma and virally mediated airway inflammation and may play a role in exacerbations of chronic obstructive pulmonary disease (COPD).
Academic Respiratory Medicine and The William Harvey Research Institute, St Bartholomew's and Royal London School of Medicine and Dentistry, London EC1A 7BE, UK.