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pubmed:otherAbstract |
PIP: A study of norethandrolone as a male oral contraceptive is presented. 4 subjects received 20 mg/day of the drug for 3 months concurrent with 2 or 3 subdermal capsule implants containing 20-mg testosterone. A considerable variation in sperm counts was observed during the cycle, though an azoospermic condition was not realized. Sperm counts in all subjects were markedly lower at some time during the treatment. Circulating levels of serum androgens, follicle-stimulating hormone, dihydrotestosterone, and testosterone were more consistently suppressed than were luteinizing hormone levels. Libido was slightly decreased in all subjects during treatment. All hormone levels returned to pretreatment values within 3 months of discontinued treatment. The amount of testosterone released from the capsules was between 32.2-36.4 mcg/cm/day. It is concluded that the dosage administered was inadequate for contraceptive purposes.
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