|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
12
|
|
pubmed:dateCreated |
2000-12-21
|
|
pubmed:abstractText |
The duration of infection and the quantity of Ag presented in vivo are commonly assumed to influence, if not determine, the magnitude of T cell responses. Although the cessation of in vivo T cell expansion coincides with bacterial clearance in mice infected with Listeria monocytogenes, closer analysis suggests that control of T cell expansion and contraction is more complex. In this report, we show that the magnitude and kinetics of Ag-specific T cell responses are determined during the first day of bacterial infection. Expansion of Ag-specific T lymphocyte populations and generation of T cell memory are independent of the duration and severity of in vivo bacterial infection. Our studies indicate that the Ag-specific T cell response to L. monocytogenes is programmed before the peak of the innate inflammatory response and in vivo bacterial replication.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Ampicillin,
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Toxins,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes, T-Lymphocyte,
http://linkedlifedata.com/resource/pubmed/chemical/H-2 Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/H-2K(K) antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Heat-Shock Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Hemolysin Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Immunodominant Epitopes,
http://linkedlifedata.com/resource/pubmed/chemical/hlyA protein, Listeria monocytogenes
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0022-1767
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
165
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
6833-9
|
|
pubmed:dateRevised |
2010-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:11120806-Adoptive Transfer,
pubmed-meshheading:11120806-Ampicillin,
pubmed-meshheading:11120806-Animals,
pubmed-meshheading:11120806-Antigen Presentation,
pubmed-meshheading:11120806-Bacterial Toxins,
pubmed-meshheading:11120806-CD8-Positive T-Lymphocytes,
pubmed-meshheading:11120806-Cell Cycle,
pubmed-meshheading:11120806-Cell Differentiation,
pubmed-meshheading:11120806-Cell Division,
pubmed-meshheading:11120806-Cytotoxicity Tests, Immunologic,
pubmed-meshheading:11120806-Epitopes, T-Lymphocyte,
pubmed-meshheading:11120806-H-2 Antigens,
pubmed-meshheading:11120806-Heat-Shock Proteins,
pubmed-meshheading:11120806-Hemolysin Proteins,
pubmed-meshheading:11120806-Immunodominant Epitopes,
pubmed-meshheading:11120806-Immunologic Memory,
pubmed-meshheading:11120806-Injections, Intravenous,
pubmed-meshheading:11120806-Listeria monocytogenes,
pubmed-meshheading:11120806-Listeriosis,
pubmed-meshheading:11120806-Lymphocyte Activation,
pubmed-meshheading:11120806-Mice,
pubmed-meshheading:11120806-Mice, Congenic,
pubmed-meshheading:11120806-Mice, Inbred BALB C,
pubmed-meshheading:11120806-Mice, Inbred C57BL,
pubmed-meshheading:11120806-Mice, Transgenic,
pubmed-meshheading:11120806-T-Lymphocyte Subsets
|
|
pubmed:year |
2000
|
|
pubmed:articleTitle |
Early programming of T cell populations responding to bacterial infection.
|
|
pubmed:affiliation |
Sections of. Infectious Diseases and Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|
