Linked Life Data

11120804

Source:http://linkedlifedata.com/resource/pubmed/id/11120804

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2000-12-21
pubmed:abstractText
In the thymic cortex, T lymphocytes are positively selected to survive and committed either to the CD4 single-positive (SP) or the CD8 SP lineage. The SP cells then pass through a step of maturation in the medulla and are delivered to peripheral lymphoid tissues. We examined the role of AML1, the gene encoding a transcription factor, in the above processes by using the transgenic mice expressing a dominant interfering form of AML1 as well as mice targeted heterozygously for AML1. One phenotypic change seen in the AML1-diminished mice was the reduction in the numbers of both CD4 SP and CD8 SP thymocytes, reflecting the partial impairment of the transition from the double-positive to SP stage. In addition, distinct from the above abnormality, perturbed were several aspects of SP cells, including the maturation of SP thymocytes, the recent thymic emigration, and the proliferative responsiveness of peripheral T cells to TCR stimulation. Interestingly, the AML1 diminution caused inhibitory and enhancing effects on the CD4 SP and CD8 SP cells, respectively. These differential effects are most likely related to the reduction in the peripheral CD4 SP/CD8 SP ratio observed in the AML1-diminished mice. The AML1 transcription factor thus maintains the homeostasis of each SP subset by functioning at the later stages of T lymphocyte differentiation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
165
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6816-24
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:11120804-Animals, pubmed-meshheading:11120804-CD4-CD8 Ratio, pubmed-meshheading:11120804-CD4-Positive T-Lymphocytes, pubmed-meshheading:11120804-CD8-Positive T-Lymphocytes, pubmed-meshheading:11120804-Cell Differentiation, pubmed-meshheading:11120804-Cell Movement, pubmed-meshheading:11120804-Cells, Cultured, pubmed-meshheading:11120804-Core Binding Factor Alpha 2 Subunit, pubmed-meshheading:11120804-Crosses, Genetic, pubmed-meshheading:11120804-DNA-Binding Proteins, pubmed-meshheading:11120804-Drosophila Proteins, pubmed-meshheading:11120804-Lymphocyte Activation, pubmed-meshheading:11120804-Lymphoid Tissue, pubmed-meshheading:11120804-Mice, pubmed-meshheading:11120804-Mice, Inbred C3H, pubmed-meshheading:11120804-Mice, Inbred C57BL, pubmed-meshheading:11120804-Mice, Transgenic, pubmed-meshheading:11120804-Nuclear Proteins, pubmed-meshheading:11120804-Phenotype, pubmed-meshheading:11120804-Proto-Oncogene Proteins, pubmed-meshheading:11120804-Receptors, Antigen, T-Cell, pubmed-meshheading:11120804-T-Lymphocyte Subsets, pubmed-meshheading:11120804-Thymus Gland, pubmed-meshheading:11120804-Transcription Factors
pubmed:year
2000
pubmed:articleTitle
Diminution of the AML1 transcription factor function causes differential effects on the fates of CD4 and CD8 single-positive T cells.
pubmed:affiliation
Department of Molecular Immunology, Institute of Development, Aging and Cancer, Tohoku University, Seiryo-machi, Aoba-ku, Sendai, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't