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rdf:type |
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lifeskim:mentions |
umls-concept:C0012854,
umls-concept:C0032136,
umls-concept:C0039195,
umls-concept:C0104998,
umls-concept:C0205245,
umls-concept:C0871261,
umls-concept:C1704632,
umls-concept:C1705431,
umls-concept:C1706817,
umls-concept:C2698599,
umls-concept:C2911692
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pubmed:issue |
12
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pubmed:dateCreated |
2000-12-21
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pubmed:abstractText |
A costimulatory signal in addition to an Ag-specific stimulus is required for optimal activation of T lymphocytes. CD28, the primary positive costimulatory receptor on T cells, has two identified ligands, B7-1 and B7-2. Whether B7-1 and B7-2 have identical, overlapping, or distinct functions remains unresolved. In this study, we show that mice lacking B7-2 were unable to generate CTL responses following immunization with a plasmid DNA vaccine. The ability of these B7-2-deficient mice to generate CTL responses following plasmid gp120 DNA vaccination was fully reconstituted by coadministering either a plasmid expressing B7-2 or B7-1. Moreover, the ability to generate CTL responses following plasmid DNA vaccination in mice lacking both B7-1 and B7-2 could be reconstituted by administering either plasmid B7-1 or plasmid B7-2 with the vaccine construct. These data demonstrate that either B7-1 or B7-2 administered concurrently with a plasmid DNA vaccine can fully costimulate vaccine-elicited CTL responses. Functional differences between B7-1 and B7-2 observed in vivo therefore may not reflect inherent differences in the interactions of CD28 with these ligands.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/AIDS Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/Adjuvants, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD80,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD86,
http://linkedlifedata.com/resource/pubmed/chemical/Cd86 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes, T-Lymphocyte,
http://linkedlifedata.com/resource/pubmed/chemical/HIV Envelope Protein gp120,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Vaccines, DNA
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
165
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6791-5
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11120800-AIDS Vaccines,
pubmed-meshheading:11120800-Adjuvants, Immunologic,
pubmed-meshheading:11120800-Amino Acid Sequence,
pubmed-meshheading:11120800-Animals,
pubmed-meshheading:11120800-Antigens, CD,
pubmed-meshheading:11120800-Antigens, CD80,
pubmed-meshheading:11120800-Antigens, CD86,
pubmed-meshheading:11120800-Cytotoxicity, Immunologic,
pubmed-meshheading:11120800-Dose-Response Relationship, Immunologic,
pubmed-meshheading:11120800-Epitopes, T-Lymphocyte,
pubmed-meshheading:11120800-HIV Envelope Protein gp120,
pubmed-meshheading:11120800-HIV-1,
pubmed-meshheading:11120800-Injections, Intramuscular,
pubmed-meshheading:11120800-Kinetics,
pubmed-meshheading:11120800-Lymphocyte Activation,
pubmed-meshheading:11120800-Membrane Glycoproteins,
pubmed-meshheading:11120800-Mice,
pubmed-meshheading:11120800-Mice, Inbred BALB C,
pubmed-meshheading:11120800-Mice, Knockout,
pubmed-meshheading:11120800-Molecular Sequence Data,
pubmed-meshheading:11120800-Plasmids,
pubmed-meshheading:11120800-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:11120800-Vaccines, DNA
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pubmed:year |
2000
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pubmed:articleTitle |
Functional equivalency of B7-1 and B7-2 for costimulating plasmid DNA vaccine-elicited CTL responses.
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pubmed:affiliation |
Department of Medicine, Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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