pubmed-article:11119573 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:11119573 | lifeskim:mentions | umls-concept:C0079382 | lld:lifeskim |
pubmed-article:11119573 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
pubmed-article:11119573 | lifeskim:mentions | umls-concept:C0021745 | lld:lifeskim |
pubmed-article:11119573 | lifeskim:mentions | umls-concept:C0035369 | lld:lifeskim |
pubmed-article:11119573 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
pubmed-article:11119573 | lifeskim:mentions | umls-concept:C0205322 | lld:lifeskim |
pubmed-article:11119573 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
pubmed-article:11119573 | lifeskim:mentions | umls-concept:C0443252 | lld:lifeskim |
pubmed-article:11119573 | pubmed:issue | 1 | lld:pubmed |
pubmed-article:11119573 | pubmed:dateCreated | 2001-1-4 | lld:pubmed |
pubmed-article:11119573 | pubmed:abstractText | We have used the Friend virus model to determine the basic mechanisms by which the immune system can control persistent retroviral infections. Previously we showed that CD4(+) T cells play an essential role in keeping persistent retrovirus in check. The present in vitro experiments with a Friend virus-specific CD4(+) T-cell clone revealed that these cells produce gamma interferon (IFN-gamma), which acts with two distinct mechanisms of antiviral activity. First, IFN-gamma had a direct inhibitory effect on virus production. This inhibitory effect was noncytolytic and, interestingly, was not associated with decreased cell surface expression of viral antigens. The second mechanism of IFN-gamma-mediated antiviral activity was an enhancement of CD4(+) T-cell-mediated cytolytic activity. We also found an in vivo role for IFN-gamma in the control of persistent Friend virus infections. Neutralization of IFN-gamma in persistently infected mice resulted in significantly increased levels of virus in the spleen, and a significant percentage of IFN-gamma-deficient mice were unable to maintain long-term control over Friend virus infections. | lld:pubmed |
pubmed-article:11119573 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11119573 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11119573 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11119573 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11119573 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11119573 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11119573 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11119573 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11119573 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11119573 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11119573 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11119573 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11119573 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11119573 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11119573 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11119573 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11119573 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11119573 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11119573 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11119573 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11119573 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11119573 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11119573 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11119573 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11119573 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11119573 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11119573 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11119573 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11119573 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11119573 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11119573 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11119573 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11119573 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11119573 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11119573 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11119573 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11119573 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11119573 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11119573 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11119573 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11119573 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11119573 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11119573 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11119573 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11119573 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11119573 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11119573 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11119573 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11119573 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11119573 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11119573 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11119573 | pubmed:language | eng | lld:pubmed |
pubmed-article:11119573 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11119573 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:11119573 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11119573 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:11119573 | pubmed:month | Jan | lld:pubmed |
pubmed-article:11119573 | pubmed:issn | 0022-538X | lld:pubmed |
pubmed-article:11119573 | pubmed:author | pubmed-author:PetersonKK | lld:pubmed |
pubmed-article:11119573 | pubmed:author | pubmed-author:MesserR JRJ | lld:pubmed |
pubmed-article:11119573 | pubmed:author | pubmed-author:HasenkrugK... | lld:pubmed |
pubmed-article:11119573 | pubmed:author | pubmed-author:IwashiroMM | lld:pubmed |
pubmed-article:11119573 | pubmed:author | pubmed-author:StromnesI MIM | lld:pubmed |
pubmed-article:11119573 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:11119573 | pubmed:volume | 75 | lld:pubmed |
pubmed-article:11119573 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:11119573 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:11119573 | pubmed:pagination | 52-60 | lld:pubmed |
pubmed-article:11119573 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
pubmed-article:11119573 | pubmed:meshHeading | pubmed-meshheading:11119573... | lld:pubmed |
pubmed-article:11119573 | pubmed:meshHeading | pubmed-meshheading:11119573... | lld:pubmed |
pubmed-article:11119573 | pubmed:meshHeading | pubmed-meshheading:11119573... | lld:pubmed |
pubmed-article:11119573 | pubmed:meshHeading | pubmed-meshheading:11119573... | lld:pubmed |
pubmed-article:11119573 | pubmed:meshHeading | pubmed-meshheading:11119573... | lld:pubmed |
pubmed-article:11119573 | pubmed:meshHeading | pubmed-meshheading:11119573... | lld:pubmed |
pubmed-article:11119573 | pubmed:meshHeading | pubmed-meshheading:11119573... | lld:pubmed |
pubmed-article:11119573 | pubmed:meshHeading | pubmed-meshheading:11119573... | lld:pubmed |
pubmed-article:11119573 | pubmed:meshHeading | pubmed-meshheading:11119573... | lld:pubmed |
pubmed-article:11119573 | pubmed:meshHeading | pubmed-meshheading:11119573... | lld:pubmed |
pubmed-article:11119573 | pubmed:meshHeading | pubmed-meshheading:11119573... | lld:pubmed |
pubmed-article:11119573 | pubmed:meshHeading | pubmed-meshheading:11119573... | lld:pubmed |
pubmed-article:11119573 | pubmed:meshHeading | pubmed-meshheading:11119573... | lld:pubmed |
pubmed-article:11119573 | pubmed:meshHeading | pubmed-meshheading:11119573... | lld:pubmed |
pubmed-article:11119573 | pubmed:year | 2001 | lld:pubmed |
pubmed-article:11119573 | pubmed:articleTitle | CD4(+) T cells and gamma interferon in the long-term control of persistent friend retrovirus infection. | lld:pubmed |
pubmed-article:11119573 | pubmed:affiliation | Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA. | lld:pubmed |
pubmed-article:11119573 | pubmed:publicationType | Journal Article | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11119573 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11119573 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11119573 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11119573 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11119573 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11119573 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11119573 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11119573 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11119573 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11119573 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11119573 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11119573 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11119573 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11119573 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11119573 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11119573 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11119573 | lld:pubmed |