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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2001-1-4
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pubmed:abstractText |
We have used the Friend virus model to determine the basic mechanisms by which the immune system can control persistent retroviral infections. Previously we showed that CD4(+) T cells play an essential role in keeping persistent retrovirus in check. The present in vitro experiments with a Friend virus-specific CD4(+) T-cell clone revealed that these cells produce gamma interferon (IFN-gamma), which acts with two distinct mechanisms of antiviral activity. First, IFN-gamma had a direct inhibitory effect on virus production. This inhibitory effect was noncytolytic and, interestingly, was not associated with decreased cell surface expression of viral antigens. The second mechanism of IFN-gamma-mediated antiviral activity was an enhancement of CD4(+) T-cell-mediated cytolytic activity. We also found an in vivo role for IFN-gamma in the control of persistent Friend virus infections. Neutralization of IFN-gamma in persistently infected mice resulted in significantly increased levels of virus in the spleen, and a significant percentage of IFN-gamma-deficient mice were unable to maintain long-term control over Friend virus infections.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11119573-10074196,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/11119573-10221919,
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
75
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
52-60
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:11119573-Animals,
pubmed-meshheading:11119573-CD4-Positive T-Lymphocytes,
pubmed-meshheading:11119573-Cell Communication,
pubmed-meshheading:11119573-Cytotoxicity, Immunologic,
pubmed-meshheading:11119573-Female,
pubmed-meshheading:11119573-Friend murine leukemia virus,
pubmed-meshheading:11119573-Interferon-gamma,
pubmed-meshheading:11119573-Mice,
pubmed-meshheading:11119573-Mice, Inbred BALB C,
pubmed-meshheading:11119573-Mice, Inbred C57BL,
pubmed-meshheading:11119573-Mice, Knockout,
pubmed-meshheading:11119573-Retroviridae Infections,
pubmed-meshheading:11119573-Tumor Cells, Cultured,
pubmed-meshheading:11119573-Tumor Virus Infections
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pubmed:year |
2001
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pubmed:articleTitle |
CD4(+) T cells and gamma interferon in the long-term control of persistent friend retrovirus infection.
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pubmed:affiliation |
Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA.
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pubmed:publicationType |
Journal Article
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