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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2001-1-18
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pubmed:abstractText |
From a panel of nine inbred mice strains intranasally infected with Streptococcus pneumoniae type 2 strain, BALB/c mice were resistant and CBA/Ca and SJL mice were susceptible to infection. Further investigation revealed that BALB/c mice were able to prevent proliferation of pneumococci in the lungs and blood, whereas CBA/Ca mice showed no bacterial clearance. Rapidly increasing numbers of bacteria in the blood was a feature of CBA/Ca but not BALB/c mice. In the lungs, BALB/c mice recruited significantly more neutrophils than CBA/Ca mice at 12 and 24 h postinfection. Inflammatory lesions in BALB/c mice were visible much earlier than in CBA/Ca mice, and there was a greater cellular infiltration into the lung tissue of BALB/c mice at the earlier time points. Our data suggest that resistance or susceptibility to intranasal pneumococci may have an association with recruitment and/or function of neutrophils.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11119534-1527438,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11119534-1729176,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11119534-3086036,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11119534-385184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11119534-3923690,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11119534-4147161,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11119534-4381896,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11119534-4403476,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11119534-606434,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11119534-6491288,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11119534-6795274,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11119534-7045675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11119534-7045676,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11119534-7076292,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11119534-7252411,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11119534-7594481,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11119534-7729877,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11119534-7927688,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11119534-8041111,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11119534-8490962,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11119534-8896500,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11119534-8918945,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11119534-8975920,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11119534-9199475,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11119534-9344781,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11119534-9488375,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11119534-9514638
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0019-9567
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pubmed:author |
pubmed-author:AlexanderJ EJE,
pubmed-author:AndrewP WPW,
pubmed-author:BoothG CGC,
pubmed-author:BrownSS,
pubmed-author:DennyPP,
pubmed-author:GinglesN ANA,
pubmed-author:HopesEE,
pubmed-author:JonesH BHB,
pubmed-author:KadiogluAA,
pubmed-author:KernMM,
pubmed-author:LittleSS,
pubmed-author:McPheatW LWL,
pubmed-author:MitchellT JTJ
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pubmed:issnType |
Print
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pubmed:volume |
69
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
426-34
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:11119534-Animals,
pubmed-meshheading:11119534-Bacteremia,
pubmed-meshheading:11119534-Genetic Predisposition to Disease,
pubmed-meshheading:11119534-H-2 Antigens,
pubmed-meshheading:11119534-Lung,
pubmed-meshheading:11119534-Mice,
pubmed-meshheading:11119534-Mice, Inbred Strains,
pubmed-meshheading:11119534-Neutrophils,
pubmed-meshheading:11119534-Pneumococcal Infections,
pubmed-meshheading:11119534-Species Specificity
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pubmed:year |
2001
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pubmed:articleTitle |
Role of genetic resistance in invasive pneumococcal infection: identification and study of susceptibility and resistance in inbred mouse strains.
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pubmed:affiliation |
Department of Microbiology and Immunology, University of Leicester, Alderley Edge, United Kingdom.
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pubmed:publicationType |
Journal Article
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