Linked Life Data

11119073

Source:http://linkedlifedata.com/resource/pubmed/id/11119073

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pubmed-article:11119073pubmed:abstractTextAn intraluminal membrane oxygenator (IMO) prototype was surgically inserted in the ileum and evaluated as a method of supporting systemic oxygenation in an acutely hypoxemic porcine model. Animals were assigned randomly to the test (n = 12) or the control (n = 8) groups, which underwent identical protocols with the exception of the O2 flow in the IMO device, which was shut off in the control group. In each case, hypoxia was induced by a reduction in the inspired oxygen fraction (FiO2) to 0.14. A highly significant improvement (p < 0.005) in arterial and venous O2 content and lower arteriovenous O2 difference (p < 0.05), cardiac output, and hemoglobin (p < 0.005) were found in the test group during hypoxia. The results show that it is possible to meet a physiologically significant portion of the body's O2 demands via the intestine during respiratory hypoxia and suggests that similar devices may be of significant potential value as a supplemental oxygenation device in cases of respiratory distress.lld:pubmed
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pubmed-article:11119073pubmed:dateRevised2007-11-15lld:pubmed
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pubmed-article:11119073pubmed:articleTitleSupplemental systemic oxygen support using an intestinal intraluminal membrane oxygenator.lld:pubmed
pubmed-article:11119073pubmed:affiliationWorcester Polytechnic Institute, Worcester, Massachusetts, USA.lld:pubmed
pubmed-article:11119073pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:11119073pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
pubmed-article:11119073pubmed:publicationTypeEvaluation Studieslld:pubmed