Source:http://linkedlifedata.com/resource/pubmed/id/11119073
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
|
| pubmed:dateCreated |
2000-12-27
|
| pubmed:abstractText |
An intraluminal membrane oxygenator (IMO) prototype was surgically inserted in the ileum and evaluated as a method of supporting systemic oxygenation in an acutely hypoxemic porcine model. Animals were assigned randomly to the test (n = 12) or the control (n = 8) groups, which underwent identical protocols with the exception of the O2 flow in the IMO device, which was shut off in the control group. In each case, hypoxia was induced by a reduction in the inspired oxygen fraction (FiO2) to 0.14. A highly significant improvement (p < 0.005) in arterial and venous O2 content and lower arteriovenous O2 difference (p < 0.05), cardiac output, and hemoglobin (p < 0.005) were found in the test group during hypoxia. The results show that it is possible to meet a physiologically significant portion of the body's O2 demands via the intestine during respiratory hypoxia and suggests that similar devices may be of significant potential value as a supplemental oxygenation device in cases of respiratory distress.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0160-564X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
24
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
864-9
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11119073-Analysis of Variance,
pubmed-meshheading:11119073-Animals,
pubmed-meshheading:11119073-Anoxia,
pubmed-meshheading:11119073-Carbon Dioxide,
pubmed-meshheading:11119073-Cardiac Output,
pubmed-meshheading:11119073-Disease Models, Animal,
pubmed-meshheading:11119073-Equipment Design,
pubmed-meshheading:11119073-Feasibility Studies,
pubmed-meshheading:11119073-Female,
pubmed-meshheading:11119073-Hemoglobins,
pubmed-meshheading:11119073-Ileum,
pubmed-meshheading:11119073-Male,
pubmed-meshheading:11119073-Mesenteric Artery, Superior,
pubmed-meshheading:11119073-Mesenteric Veins,
pubmed-meshheading:11119073-Oxygen,
pubmed-meshheading:11119073-Oxygenators, Membrane,
pubmed-meshheading:11119073-Prostheses and Implants,
pubmed-meshheading:11119073-Random Allocation,
pubmed-meshheading:11119073-Regional Blood Flow,
pubmed-meshheading:11119073-Respiratory Insufficiency,
pubmed-meshheading:11119073-Swine
|
| pubmed:year |
2000
|
| pubmed:articleTitle |
Supplemental systemic oxygen support using an intestinal intraluminal membrane oxygenator.
|
| pubmed:affiliation |
Worcester Polytechnic Institute, Worcester, Massachusetts, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Evaluation Studies
|