Source:http://linkedlifedata.com/resource/pubmed/id/11117785
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
12
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pubmed:dateCreated |
2000-12-14
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pubmed:abstractText |
It has been considered that gastric large B cell lymphoma mainly consists of mucosa-associated lymphoid tissue lymphoma (MALToma) with large cell transformation. However, debate continues about the cell lineage. We analyzed 61 operated cases of gastric B cell lymphoma, mainly focusing on 40 cases of diffuse large cell lymphoma (DLCL). Immunohistologically, two cases were classified as CD10-positive follicular lymphoma, 19 cases were low-grade MALToma, 11 CD10-negative DLCL with a component of low-grade MALToma (high-grade MALToma), 12 CD10-positive DLCL, and 17 CD10-negative DLCL without MALToma (pure DLCL). Lymphoepithelial lesion (LEL) was found in all -cases of high-grade MALToma, and in eight of these its invasion was confined to the mucosa and submucosa. Expression of Bcl-6 was detected in two cases of high-grade MALToma. Only two cases of CD10-positive DLCL had large cell LEL, and seven cases showed tumor invasion beyond the submucosa. All 12 cases were positive for Bcl-6, and a delicate meshwork of CD35 (Ber-MAC-DRC)-positive follicular dendritic cells was detected in eight cases. Pure DLCL of all 17 cases reached the proper muscle layer or more, and expression of Bcl-6 was detected in 10 cases. For patients with pure DLCL, overall survival was significantly (p <0.05) worse than those of high-grade MALToma and CD10-positive DLCL by Kaplan-Meier and log-rank methods. Clinical staging and Bcl-6 expression were also good prognostic factors in patients with DLCL. Three groups of gastric DLCL each had unique histologic findings, immunohistologic characteristics, and prognosis.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0147-5185
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1641-9
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:11117785-Aged,
pubmed-meshheading:11117785-Female,
pubmed-meshheading:11117785-Humans,
pubmed-meshheading:11117785-Immunohistochemistry,
pubmed-meshheading:11117785-Lymphoma, B-Cell,
pubmed-meshheading:11117785-Lymphoma, B-Cell, Marginal Zone,
pubmed-meshheading:11117785-Lymphoma, Large B-Cell, Diffuse,
pubmed-meshheading:11117785-Lymphoma, Non-Hodgkin,
pubmed-meshheading:11117785-Male,
pubmed-meshheading:11117785-Middle Aged,
pubmed-meshheading:11117785-Neprilysin,
pubmed-meshheading:11117785-Prognosis,
pubmed-meshheading:11117785-Stomach Neoplasms,
pubmed-meshheading:11117785-Survival Analysis
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pubmed:year |
2000
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pubmed:articleTitle |
Histologic and immunohistologic findings and prognosis of 40 cases of gastric large B-cell lymphoma.
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pubmed:affiliation |
Department of Pathology, Clinical Laboratory, National Kyushu Medical Center Hospital, Fukuoka, Japan. mota@sv02.qmed2.hosp.go.jp
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pubmed:publicationType |
Journal Article
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