Source:http://linkedlifedata.com/resource/pubmed/id/11117432
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
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| pubmed:dateCreated |
2000-12-14
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| pubmed:abstractText |
The sulphonylurea receptor-1 (SUR-1) regulates glucose-induced insulin secretion by controlling K+-ATP channel activity of the pancreatic beta-cell membrane. In this study, we investigated the putative role of a T/G-polymorphism (exon 33, codon 1369; S1369A) in the adenosine diphosphate-sensing nucleotide-binding fold-2 (NBF-2) of the SUR-1 on glucose-induced insulin secretion during an oral glucose tolerance test in pregnant women (PW; n=182). Compared to PW with the T/T genotype, statistically significant elevated C-peptide concentrations were found 60 min after glucose intake in PW with the T/G and G/G genotype (T/T 9.0+/-0.4 ng/ml vs T/G 10.8+/-0.4 ng/ml or G/G 10.8+/-0.7 ng/ml, p=0.01). Furthermore, compared to PW with T/T genotype the deltaC-peptide (60/0 min) was significantly enhanced in PW with T/G or G/G genotype (T/T 6.7+/-0.3 vs T/G 8.9+/-0.4 or G/G 8.9+/-0.7, p=0.0009). A significant correlation of C-peptide concentrations with blood glucose (BG) 60 min after glucose intake was only found in PW with the T/T genotype (r=0.6, p<0.0004). Similarly, a significant correlation of insulin concentrations with BG 60 min after glucose intake was observed in PW with T/T genotype (r=0.5, p<0.0001) and T/G genotype (r=0.24, p<0.03) but not in PW with G/G genotype (r=0.01, p=0.9). From our data we conclude that in PW with the alanine substitution in the NBF-2 region, the insulin response of the pancreatic beta-cell after glucose intake is enhanced and does not correlate with actual BG levels.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ATP-Binding Cassette Transporters,
http://linkedlifedata.com/resource/pubmed/chemical/Alanine,
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/C-Peptide,
http://linkedlifedata.com/resource/pubmed/chemical/Codon,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels, Inwardly...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Drug,
http://linkedlifedata.com/resource/pubmed/chemical/Serine,
http://linkedlifedata.com/resource/pubmed/chemical/sulfonylurea receptor
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| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
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| pubmed:issn |
0141-8955
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
23
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
705-12
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:11117432-ATP-Binding Cassette Transporters,
pubmed-meshheading:11117432-Alanine,
pubmed-meshheading:11117432-Binding Sites,
pubmed-meshheading:11117432-Blood Glucose,
pubmed-meshheading:11117432-C-Peptide,
pubmed-meshheading:11117432-Codon,
pubmed-meshheading:11117432-Diabetes, Gestational,
pubmed-meshheading:11117432-Exons,
pubmed-meshheading:11117432-Female,
pubmed-meshheading:11117432-Genetic Variation,
pubmed-meshheading:11117432-Glucose,
pubmed-meshheading:11117432-Humans,
pubmed-meshheading:11117432-Insulin,
pubmed-meshheading:11117432-Polymorphism, Genetic,
pubmed-meshheading:11117432-Potassium Channels,
pubmed-meshheading:11117432-Potassium Channels, Inwardly Rectifying,
pubmed-meshheading:11117432-Pregnancy,
pubmed-meshheading:11117432-Receptors, Drug,
pubmed-meshheading:11117432-Serine
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| pubmed:year |
2000
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| pubmed:articleTitle |
A serine/alanine polymorphism in the nucleotide-binding fold-2 of the sulphonylurea receptor-1 (S1369A) is associated with enhanced glucose-induced insulin secretion during pregnancy.
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| pubmed:affiliation |
Institute of Clinical Chemistry, Municipal Hospital Rudolfstiftung, Vienna, Austria. walter.krugluger@kar.magwien.gv.at
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| pubmed:publicationType |
Journal Article
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