Linked Life Data

11116219

Source:http://linkedlifedata.com/resource/pubmed/id/11116219

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2000-12-20
pubmed:abstractText
Metabotropic glutamate receptors (mGluRs) are potential participants of sensory-dependent modification of neural connections. Here, we examined the involvement of cAMP-linked mGluRs (mGluR2/3) in sensory-dependent plasticity by studying the correlation of mGluR2/3 changes with the critical period of ocular dominance plasticity, a form of sensory-dependent plasticity, and exploring the effects of dark rearing on mGluR2/3 in the primary visual cortex of cats. Immunohistochemistry showed that the laminar distribution of mGluR2/3 changed with the critical period and was sensitive to dark rearing. The mGluR2/3 immunostaining became most intense in layer IV at the beginning of the critical period and was reduced in layer IV but became intense in layers I-III at the peak of the period, then was concentrated primarily in layers I-upper III at the end of the critical period. Dark rearing delayed these pattern changes for weeks and elevated the normally declining mGluR2/3 quantity shortly after the peak of the critical period. The effects of dark rearing and the correlation of early mGluR2/3 laminar changes with geniculocortical afferent segregation indicate that mGluR2/3 circuitry in the visual cortex is influenced by visual inputs. Our data suggest that mGluR2/3 together with another sensory-influenced mGluR, mGluR5, may participate in the sensory-dependent modification of neural connections in the visual cortex.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0021-9967
pubmed:author
pubmed:copyrightInfo
Copyright 2000 Wiley-Liss, Inc.
pubmed:issnType
Print
pubmed:day
8
pubmed:volume
429
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
270-6
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Developmental and sensory-dependent changes of group II metabotropic glutamate receptors.
pubmed:affiliation
Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut 06520-8061, USA. reiddrs@aol.com
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't