Source:http://linkedlifedata.com/resource/pubmed/id/11114526
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
23
|
| pubmed:dateCreated |
2000-12-29
|
| pubmed:abstractText |
The idea of using simple, genetically tractable host organisms to study the virulence mechanisms of pathogens dates back at least to the work of Darmon and Depraitère [1]. They proposed using the predatory amoeba Dictyostelium discoideum as a model host, an approach that has proved to be valid in the case of the intracellular pathogen Legionella pneumophila [2]. Research from the Ausubel laboratory has clearly established the nematode Caenorhabditis elegans as an attractive model host for the study of Pseudomonas aeruginosa pathogenesis [3]. P. aeruginosa is a bacterium that is capable of infecting plants, insects and mammals. Other pathogens with a similarly broad host range have also been shown to infect C. elegans [3,4]. Nevertheless, the need to determine the universality of C. elegans as a model host, especially with regards pathogens that have a naturally restricted host specificity, has rightly been expressed [5]. We report here that the enterobacterium Salmonella typhimurium, generally considered to be a highly adapted pathogen with a narrow range of target hosts [6], is capable of infecting and killing C. elegans. Furthermore, mutant strains that exhibit a reduced virulence in mammals were also attenuated for their virulence in C. elegans, showing that the nematode may constitute a useful model system for the study of this important human pathogen.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0960-9822
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
30
|
| pubmed:volume |
10
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1543-5
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:11114526-Animals,
pubmed-meshheading:11114526-Caenorhabditis elegans,
pubmed-meshheading:11114526-Disease Models, Animal,
pubmed-meshheading:11114526-Hot Temperature,
pubmed-meshheading:11114526-Humans,
pubmed-meshheading:11114526-Hydrogen-Ion Concentration,
pubmed-meshheading:11114526-Intestines,
pubmed-meshheading:11114526-Mutation,
pubmed-meshheading:11114526-Pharynx,
pubmed-meshheading:11114526-Salmonella Infections,
pubmed-meshheading:11114526-Salmonella typhimurium,
pubmed-meshheading:11114526-Virulence
|
| pubmed:year |
2000
|
| pubmed:articleTitle |
Caenorhabditis elegans is a model host for Salmonella typhimurium.
|
| pubmed:affiliation |
Centre d'Immunologie de Marseille-Luminy, INSERM/CNRS/Université de la Méditerranée, Case 906, 13288 Cedex 9,., Marseille, France.
|
| pubmed:publicationType |
Journal Article
|