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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2001-1-10
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pubmed:abstractText |
The serotonin transporter (5-HTT) gene is a candidate gene in alcohol dependence because serotonin reuptake inhibitors (SRIs) can alleviate alcohol withdrawal. Studies of the 5-HTT gene in alcohol dependence have not resulted in a consensus. Recent studies have examined the transcriptionally active promoter polymorphism, a 44-bp deletion resulting in short (S) or long (L) alleles. In this study, 131 alcohol-dependent patients of Northern and Western European descent were genotyped. Seventy of these patients were diagnosed with alcohol dependence without comorbid disorders. Sixty-one patients were diagnosed with alcohol dependence comorbid with Tourette syndrome (alcoholic-TS). We found an excess of the S allele in alcohol-dependent patients (47%) compared with 125 ethnically matched controls (39%). A similar trend was found in 150 ethnically matched TS patients without alcohol dependence comorbidity (51%). However, the statistical significance of this trend in the data was not present after Bonferroni correction. The data presented suggests a trend toward increased frequency of the S promoter allele in alcohol-dependent, alcoholic-TS and TS patients.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0741-8329
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
61-7
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11113619-Adult,
pubmed-meshheading:11113619-Alcoholism,
pubmed-meshheading:11113619-Alleles,
pubmed-meshheading:11113619-Carrier Proteins,
pubmed-meshheading:11113619-Gene Frequency,
pubmed-meshheading:11113619-Genotype,
pubmed-meshheading:11113619-Humans,
pubmed-meshheading:11113619-Linkage Disequilibrium,
pubmed-meshheading:11113619-Membrane Glycoproteins,
pubmed-meshheading:11113619-Membrane Transport Proteins,
pubmed-meshheading:11113619-Middle Aged,
pubmed-meshheading:11113619-Minisatellite Repeats,
pubmed-meshheading:11113619-Nerve Tissue Proteins,
pubmed-meshheading:11113619-Polymerase Chain Reaction,
pubmed-meshheading:11113619-Polymorphism, Genetic,
pubmed-meshheading:11113619-Promoter Regions, Genetic,
pubmed-meshheading:11113619-Serotonin Plasma Membrane Transport Proteins,
pubmed-meshheading:11113619-Tourette Syndrome
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pubmed:year |
2000
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pubmed:articleTitle |
Serotonin transporter gene polymorphisms in alcohol dependence.
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pubmed:affiliation |
Department of Pharmacology, University of Toronto, M5S 2S1, Toronto, Ontario, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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