Linked Life Data

11113345

Source:http://linkedlifedata.com/resource/pubmed/id/11113345

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2001-1-22
pubmed:abstractText
Interleukin-1beta acts on the CNS to induce fever, neuroendocrine activation and behavioural depression. We have previously demonstrated that interleukin-1beta is synthesized in glial cells and macrophages of circumventricular organs and choroid plexus after intraperitoneal administration of bacterial lipopolysaccharide. Whether, and how, interleukin-1beta produced in glial cells affects neuronal functioning is unknown. Diffusion throughout the extracellular space is an important pathway by which factors produced by glial cells act on distant cells, a phenomenon coined "volume transmission". The present study assessed diffusion of recombinant rat interleukin-1beta, recombinant human interleukin-1 receptor antagonist and 10mol. wt dexran in the rat CNS after intracerebroventricular administration to model interleukin-1beta release from choroid plexus. Immunocytochemistry with specific antibodies directed against interleukin-1beta and interleukin-1 receptor antagonist revealed that these molecules rapidly penetrated into periventricular tissue and spread along white matter fibre bundles and blood vessels in the caudoputamen, hypothalamus and amygdala. The transcription factor nuclear factor kappa B and the immediate-early gene product Fos were detected immunocytochemically to reveal interleukin-1beta action. Intracerebroventricular infusion of interleukin-1beta induced nuclear factor kappa B translocation in choroid plexus, ependymal cells, basolateral amygdala, cerebral vasculature and meninges. Fos immunoreactivity was found in the supraoptic and paraventricular hypothalamus and central amygdala. We propose that intracerebroventricular injected interleukin-1beta can enter the brain parenchyma and act as a "volume transmission" signal in, for example, the basolateral amygdala where it might activate a neuronal projection to the central amygdala.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0306-4522
pubmed:author
pubmed:issnType
Print
pubmed:volume
101
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
957-67
pubmed:dateRevised
2009-11-3
pubmed:meshHeading
pubmed-meshheading:11113345-Animals, pubmed-meshheading:11113345-Biological Transport, pubmed-meshheading:11113345-Brain, pubmed-meshheading:11113345-Dextrans, pubmed-meshheading:11113345-Diffusion, pubmed-meshheading:11113345-Humans, pubmed-meshheading:11113345-Immunohistochemistry, pubmed-meshheading:11113345-Injections, Intraventricular, pubmed-meshheading:11113345-Interleukin 1 Receptor Antagonist Protein, pubmed-meshheading:11113345-Interleukin-1, pubmed-meshheading:11113345-Male, pubmed-meshheading:11113345-NF-kappa B, pubmed-meshheading:11113345-Neurons, pubmed-meshheading:11113345-Proto-Oncogene Proteins c-fos, pubmed-meshheading:11113345-Rats, pubmed-meshheading:11113345-Rats, Wistar, pubmed-meshheading:11113345-Recombinant Proteins, pubmed-meshheading:11113345-Sialoglycoproteins, pubmed-meshheading:11113345-Time Factors, pubmed-meshheading:11113345-Tissue Distribution
pubmed:year
2000
pubmed:articleTitle
Diffusion and action of intracerebroventricularly injected interleukin-1 in the CNS.
pubmed:affiliation
INSERM U394, Neurobiologie Intégrative, Institut François Magendie, Rue Camille Saint-Saëns, 33077, Cedex, Bordeaux, France. jpkonsman@hotmail.com
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't