Linked Life Data

11113012

Source:http://linkedlifedata.com/resource/pubmed/id/11113012

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2001-1-16
pubmed:abstractText
Patients with hypertrophic cardiomyopathy (HCM) exhibit variable expression of left ventricular hypertrophy (LVH), a major determinant of mortality and morbidity, which is partly due to the diversity of causal mutations, genetic background (modifier genes), and probably environmental factors. We determined association of functional variants of tumor necrosis factor (TNF)- alpha, interleukin-6 (IL6), insulin-like growth factor-2 (IGF2), transforming growth factor- beta 1 (TGFB1), and aldosterone synthase (CYP11B2) genes, all previously implicated in cardiac hypertrophy, with the severity of LVH in patients with HCM. Two-dimensional echocardiography was performed and demographic variables were recorded in 142 genetically independent patients. Indices of LVH including interventricular septal thickness (IVST), left ventricular mass index (LVMI), and LVH score were measured/calculated. TNF-alpha-308G/A, IL6-174G/C, IGF2 820G/A, TGFB1-509C/T, and CYP11B2-344T/C genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Genotypes were identified by the presence of specific electrophoretic patterns and their distributions were according to the Hardy-Weinberg equilibrium. Demographic variables were not significantly different among the genotypes. Subjects with the AA genotype of TNF-alpha (n=8) were approximately 13 years younger at the time of clinical diagnosis. Despite a younger age, they had a greater mean LVMI than those with the GG (n=94) or GA (n=33) genotypes (191.8+/-59.5 v 139.1+/-47.3 v 132.1+/-34.3, respectively, P=0.004). TNF-alpha-308G/A genotypes accounted for 6.0% of variability of LVMI (P=0.002). Mean IVST, LVEDD, and LVH score were not significantly different. Variants of IL6, IGF2, TGFB1, and CYP11B2 were not associated with indices of LVH. The uncommon allele of TNF-alpha-308G/A polymorphism, known to produce more TNF- alpha, was associated with greater LVMI and clinical diagnosis at a younger age in patients with HCM. Functional variants of other trophic factors, previously implicated in cardiac hypertrophy, were not associated with the indices of LVH. These results suggest that TNF-alpha is a modifier gene for HCM.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0022-2828
pubmed:author
pubmed:copyrightInfo
Copyright 2000 Academic Press.
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2369-77
pubmed:dateRevised
2010-12-3
pubmed:meshHeading
pubmed-meshheading:11113012-Adult, pubmed-meshheading:11113012-Age Factors, pubmed-meshheading:11113012-Aged, pubmed-meshheading:11113012-Aldosterone Synthase, pubmed-meshheading:11113012-Alleles, pubmed-meshheading:11113012-Cardiomyopathy, Hypertrophic, pubmed-meshheading:11113012-Echocardiography, pubmed-meshheading:11113012-Female, pubmed-meshheading:11113012-Genotype, pubmed-meshheading:11113012-Humans, pubmed-meshheading:11113012-Insulin-Like Growth Factor II, pubmed-meshheading:11113012-Interleukin-6, pubmed-meshheading:11113012-Male, pubmed-meshheading:11113012-Middle Aged, pubmed-meshheading:11113012-Polymerase Chain Reaction, pubmed-meshheading:11113012-Polymorphism, Genetic, pubmed-meshheading:11113012-Polymorphism, Restriction Fragment Length, pubmed-meshheading:11113012-Transforming Growth Factor beta, pubmed-meshheading:11113012-Transforming Growth Factor beta1, pubmed-meshheading:11113012-Tumor Necrosis Factor-alpha
pubmed:year
2000
pubmed:articleTitle
Variants of trophic factors and expression of cardiac hypertrophy in patients with hypertrophic cardiomyopathy.
pubmed:affiliation
Section of Cardiology, Baylor College of Medicine, Houston, Texas 77030, USA.
pubmed:publicationType
Journal Article