Linked Life Data

11112144

Source:http://linkedlifedata.com/resource/pubmed/id/11112144

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2001-1-24
pubmed:abstractText
In patients with chronic obstructive pulmonary disease (COPD), differentiating a pulmonary embolism (PE) from an exacerbation of COPD can be difficult, since clinical signs and symptoms of the two conditions overlap. Development of reliable noninvasive or minimally invasive techniques for the diagnosis of PE is, especially in these patients, necessary. In this study we assessed the effect of COPD on the accuracy of the clinical probability estimate (CPE), spiral computed tomographic angiography (SCTA), D-dimer analysis, ventilation perfusion (V/Q) scintigraphy, and pulmonary angiography for the diagnosis of PE. From May 1997 through March 1998, 627 consecutive patients with suspected PE were investigated in six teaching hospitals. In these patients, D-dimer testing, CPE, V/Q scintigraphy, and SCTA and/or pulmonary angiography were performed according to a strict diagnostic protocol. The patients were also independently categorized as having COPD or not. A diagnosis of COPD was established in 91 patients (15%). The prevalence of PE was similar in patients with and without COPD (29% and 31%, respectively), notwithstanding the larger proportion of nondiagnostic V/Q scan results in patients with COPD (46% versus 21%, p < 0.001). The distribution of CPEs, diagnostic value of the D-dimer assay and SCTA, and reproducibility of pulmonary angiography were comparable among patients with and without COPD. The presence of COPD does not affect the diagnostic performance of CPE, D-dimer testing, SCTA, or pulmonary angiography. Furthermore, although more nondiagnostic V/Q scan results can be expected in the presence of COPD, V/Q scintigraphy remains a valuable screening test in patients with COPD.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1073-449X
pubmed:author
pubmed:issnType
Print
pubmed:volume
162
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2232-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:11112144-Acute Disease, pubmed-meshheading:11112144-Aged, pubmed-meshheading:11112144-Algorithms, pubmed-meshheading:11112144-Angiography, pubmed-meshheading:11112144-Diagnosis, Differential, pubmed-meshheading:11112144-Female, pubmed-meshheading:11112144-Fibrin Fibrinogen Degradation Products, pubmed-meshheading:11112144-Humans, pubmed-meshheading:11112144-Logistic Models, pubmed-meshheading:11112144-Lung, pubmed-meshheading:11112144-Lung Diseases, Obstructive, pubmed-meshheading:11112144-Male, pubmed-meshheading:11112144-Middle Aged, pubmed-meshheading:11112144-Netherlands, pubmed-meshheading:11112144-Observer Variation, pubmed-meshheading:11112144-Probability, pubmed-meshheading:11112144-Prospective Studies, pubmed-meshheading:11112144-Pulmonary Embolism, pubmed-meshheading:11112144-Tomography, X-Ray Computed, pubmed-meshheading:11112144-Ventilation-Perfusion Ratio
pubmed:year
2000
pubmed:articleTitle
Diagnosing acute pulmonary embolism: effect of chronic obstructive pulmonary disease on the performance of D-dimer testing, ventilation/perfusion scintigraphy, spiral computed tomographic angiography, and conventional angiography. ANTELOPE Study Group. Advances in New Technologies Evaluating the Localization of Pulmonary Embolism.
pubmed:affiliation
Department of Radiology, University Medical Center, Utrecht, The Netherlands. I.J.C.Hartmann@azu.nl
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't, Multicenter Study