Linked Life Data

11111848

Source:http://linkedlifedata.com/resource/pubmed/id/11111848

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2001-2-16
pubmed:abstractText
We have studied migrating motor complexes (MMCs) in the isolated terminal ileum or colon (IMMCs and CMMCs respectively) of the C57BL/6 mouse. Periodic contractions occurred spontaneously in both preparations in the absence of intraluminal stimulation. After an initial period, complexes became synchronized between the oral and anal ends of the tissue, and could be observed for in excess of 7 h. The propagation velocity was 3.1+/-1.0 and 3.9+/-0.6 mm s(-1) in the ileum and colon respectively. IMMCs occurred every 6.01+/-0.39 min and had a duration of 86.3+/-10.4 s. The interval between CMMCs was smaller (3.52+/-0.31 min) and contractions were shorter in duration (30.7+/-3.6 s). In both preparations, these motor events were dependent on cholinergic transmission: blocked by hexamethonium (500 microM) and attenuated or blocked by atropine (1 microM). This study is the first demonstration of spontaneous migrating contractions in the isolated ileum or colon of the C57BL/6 mouse, the strain of choice for neurological transgenic and targeted mice.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1566-0702
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
84
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
162-8
pubmed:dateRevised
2009-8-12
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Spontaneous migrating motor complexes occur in both the terminal ileum and colon of the C57BL/6 mouse in vitro.
pubmed:affiliation
Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno 89557-0046, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't