Linked Life Data

1111174

Source:http://linkedlifedata.com/resource/pubmed/id/1111174

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1975-4-17
pubmed:abstractText
The in vitro metabolism of 2,2-3-H-androstenedione by the pituitary, hypothalamus, and hippocampus of intact and castrated adult male rats was studied. Conversion of androstenedione to radiochemically pure 5alpha-androstanedione, testosterone, 5alpha-dihydrotestosterone, androsterone, and traces of 3alpha, 5alpha-androstanediol was demonstrated in minced preparations of the three tissues in the absence of cofactors. 5alpha-androstanedione was the metabolite formed in the highest proportion. The pituitary showed the highest enzymatic conversions followed in decreasing order by the hippocampus and the hypothalamus. Castration performed three weeks prior to the experiments resulted in a significant decrease of pituitary 17beta-old-dehydrogenase activity with a concomitant increase of 5alpha-reductase. No significant changes were observed after castration in the hypothalamus and the hippocampus.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0039-128X
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
53-62
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
In vitro metabolism of 3-H-androstenedione by the male rat pituitary, hypothalamus, and hippocampus.
pubmed:publicationType
Journal Article