Source:http://linkedlifedata.com/resource/pubmed/id/11109029
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
29
|
| pubmed:dateCreated |
2000-12-13
|
| pubmed:abstractText |
In the majority of people with familial hypercholesterolaemia (FH) the disorder is caused by a mutation of the low-density lipoprotein receptor gene that impairs its proper function, resulting in very high levels of plasma cholesterol. Such levels result in early and severe atherosclerosis, and hence substantial excess mortality from coronary heart disease. Most people with FH are undiagnosed or only diagnosed after their first coronary event, but early detection and treatment with hydroxymethylglutaryl-coenzyme (HMG CoA) reductase inhibitors (statins) can reduce morbidity and mortality. The prevalence of FH in the UK population is estimated to be 1 in 500, which means that approximately 110,000 people are affected.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
1366-5278
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
4
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1-123
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:11109029-Adult,
pubmed-meshheading:11109029-Aged,
pubmed-meshheading:11109029-Algorithms,
pubmed-meshheading:11109029-Attitude to Health,
pubmed-meshheading:11109029-Child,
pubmed-meshheading:11109029-Cost-Benefit Analysis,
pubmed-meshheading:11109029-Decision Trees,
pubmed-meshheading:11109029-Female,
pubmed-meshheading:11109029-Great Britain,
pubmed-meshheading:11109029-Humans,
pubmed-meshheading:11109029-Hyperlipoproteinemia Type II,
pubmed-meshheading:11109029-Male,
pubmed-meshheading:11109029-Mass Screening,
pubmed-meshheading:11109029-Middle Aged,
pubmed-meshheading:11109029-Models, Econometric,
pubmed-meshheading:11109029-Morbidity,
pubmed-meshheading:11109029-Needs Assessment,
pubmed-meshheading:11109029-Practice Guidelines as Topic,
pubmed-meshheading:11109029-Research Design,
pubmed-meshheading:11109029-Technology Assessment, Biomedical
|
| pubmed:year |
2000
|
| pubmed:articleTitle |
Screening for hypercholesterolaemia versus case finding for familial hypercholesterolaemia: a systematic review and cost-effectiveness analysis.
|
| pubmed:affiliation |
The London School of Hygiene and Tropical Medicine, Department of Public Health and Policy, Health Promotion Research Unit, London, UK.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Review,
Research Support, Non-U.S. Gov't,
Evaluation Studies
|