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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
23
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pubmed:dateCreated |
2000-12-26
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pubmed:abstractText |
Multidrug resistance-associated protein (MRP) 1 and canalicular multispecific organic anion transporter (cMOAT or MRP2) are adenosine triphosphate-binding cassette transporters that confer resistance to anticancer agents. In addition to these two transporters, there are at least four other human MRP subfamily members (MRP3 through MRP6). We and others reported previously that MRP3 is capable of conferring resistance to certain anticancer agents. In this study, we investigated whether MRP4 (MOAT-B), whose transcript accumulates to the highest levels in prostate tissue, has the capacity to confer drug resistance.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acrylates,
http://linkedlifedata.com/resource/pubmed/chemical/Anion Transport Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Antibiotics, Antineoplastic,
http://linkedlifedata.com/resource/pubmed/chemical/Antimetabolites, Antineoplastic,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, Phytogenic,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/Methotrexate,
http://linkedlifedata.com/resource/pubmed/chemical/P-Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Polymers,
http://linkedlifedata.com/resource/pubmed/chemical/poly(2-methoxyethylacrylate)
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0027-8874
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
6
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pubmed:volume |
92
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1934-40
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11106685-3T3 Cells,
pubmed-meshheading:11106685-Acrylates,
pubmed-meshheading:11106685-Animals,
pubmed-meshheading:11106685-Anion Transport Proteins,
pubmed-meshheading:11106685-Antibiotics, Antineoplastic,
pubmed-meshheading:11106685-Antimetabolites, Antineoplastic,
pubmed-meshheading:11106685-Antineoplastic Agents,
pubmed-meshheading:11106685-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:11106685-Carrier Proteins,
pubmed-meshheading:11106685-Cloning, Molecular,
pubmed-meshheading:11106685-DNA, Complementary,
pubmed-meshheading:11106685-Drug Resistance, Multiple,
pubmed-meshheading:11106685-Drug Resistance, Neoplasm,
pubmed-meshheading:11106685-Drug Screening Assays, Antitumor,
pubmed-meshheading:11106685-Humans,
pubmed-meshheading:11106685-Immunoblotting,
pubmed-meshheading:11106685-Immunohistochemistry,
pubmed-meshheading:11106685-Male,
pubmed-meshheading:11106685-Methotrexate,
pubmed-meshheading:11106685-Mice,
pubmed-meshheading:11106685-P-Glycoproteins,
pubmed-meshheading:11106685-Polymers,
pubmed-meshheading:11106685-Prostate,
pubmed-meshheading:11106685-Transfection
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pubmed:year |
2000
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pubmed:articleTitle |
Analysis of the MRP4 drug resistance profile in transfected NIH3T3 cells.
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pubmed:affiliation |
Medical Sciences Division, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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