Source:http://linkedlifedata.com/resource/pubmed/id/11105913
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2001-3-6
|
| pubmed:abstractText |
A commercial preparation of a sodium polystyrene sulfonate (designated as N-PSS; its molecular weight is 500000 daltons) was tested as an inhibitor of sperm function and as a preventive agent for conception and the transmission of sexually transmitted diseases. The polymer is an irreversible inhibitor of hyaluronidase and acrosin; its IC50 values are 5.7 microg/mL and 0.5 microg/mL, for hyaluronidase and acrosin, respectively. N-PSS is also a stimulus of human sperm acrosomal loss. It produces maximal acrosomal loss at 2.5 microg/mL. Contraception in rabbits is nearly complete when rabbit spermatozoa are pretreated with 0.5 mg/mL of N-PSS before artificial insemination; however, N-PSS does not immobilize spermatozoa at concentrations as high as 50 mg/mL. N-PSS has broad spectrum antiviral and antibacterial activities. Infection by human immunodeficiency virus and herpes simplex virus are inhibited by N-PSS; 3-log reductions are produced by 7 microg/mL and 3 microg/mL, respectively. N-PSS is active against Chlamydia trachomatis and Neisseria gonorrhoeae. At 1 mg/mL, N-PSS inhibits chlamydial infectivity by more than 90%. N-PSS produces a 3-log reduction in gonococcal growth at 15 microg/mL. In contrast, N-PSS (5 mg/mL) does not affect the growth of Lactobacillus (normal component of the vaginal flora). N-PSS can be classified as a noncytotoxic contraceptive antimicrobial agent. These properties justify bringing a polystyrene sulfonate into clinical trials for its evaluation as a preventive agent for conception and several sexually transmitted diseases.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Bacterial Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Infective Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Antiviral Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Hyaluronoglucosaminidase,
http://linkedlifedata.com/resource/pubmed/chemical/Polystyrenes,
http://linkedlifedata.com/resource/pubmed/chemical/Spermatocidal Agents,
http://linkedlifedata.com/resource/pubmed/chemical/polystyrene sulfonic acid
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0196-3635
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
21
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
862-75
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:11105913-Animals,
pubmed-meshheading:11105913-Anti-Bacterial Agents,
pubmed-meshheading:11105913-Anti-Infective Agents,
pubmed-meshheading:11105913-Antiviral Agents,
pubmed-meshheading:11105913-Chlamydia trachomatis,
pubmed-meshheading:11105913-Female,
pubmed-meshheading:11105913-HIV,
pubmed-meshheading:11105913-Humans,
pubmed-meshheading:11105913-Hyaluronoglucosaminidase,
pubmed-meshheading:11105913-Insemination, Artificial,
pubmed-meshheading:11105913-Male,
pubmed-meshheading:11105913-Microbial Sensitivity Tests,
pubmed-meshheading:11105913-Neisseria gonorrhoeae,
pubmed-meshheading:11105913-Polystyrenes,
pubmed-meshheading:11105913-Rabbits,
pubmed-meshheading:11105913-Sexually Transmitted Diseases,
pubmed-meshheading:11105913-Simplexvirus,
pubmed-meshheading:11105913-Spermatocidal Agents,
pubmed-meshheading:11105913-Spermatozoa
|
| pubmed:articleTitle |
Evaluation of poly(styrene-4-sulfonate) as a preventive agent for conception and sexually transmitted diseases.
|
| pubmed:affiliation |
TOPCAD Program and the Department of Obstetrics and Gynecology, Rush Medical Center, Chicago, Illinois 60612, USA. randerso@rpslmc.edu
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|