|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
8
|
|
pubmed:dateCreated |
2000-12-13
|
|
pubmed:abstractText |
Epidermoid anal canal carcinomas are radio- and chemosensitive tumors. Within a few decades, conservative treatment has replaced mutilating surgery as standard therapeutic practice. Exclusive high-dose radiotherapy remains the standard treatment of early stages T1-T2 N0 smaller than 4 cm. Three phase III trials demonstrated the benefits of combined chemotherapy and irradiation on the local efficacy and colostomy-free survival. Mitomycin C and 5 FU were delivered on weeks 1 and 5 of the irradiation. Concomitant 5 FU and CDDP regimen and neoadjuvant chemotherapy were evaluated on phase II trials. Ongoing intensification phase III trials are described.
|
|
pubmed:language |
fre
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
0003-3944
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
125
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
717-25
|
|
pubmed:dateRevised |
2009-11-11
|
|
pubmed:meshHeading |
pubmed-meshheading:11105342-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:11105342-Anus Neoplasms,
pubmed-meshheading:11105342-Carcinoma, Squamous Cell,
pubmed-meshheading:11105342-Cisplatin,
pubmed-meshheading:11105342-Clinical Trials, Phase II as Topic,
pubmed-meshheading:11105342-Clinical Trials, Phase III as Topic,
pubmed-meshheading:11105342-Colostomy,
pubmed-meshheading:11105342-Combined Modality Therapy,
pubmed-meshheading:11105342-Fluorouracil,
pubmed-meshheading:11105342-Humans,
pubmed-meshheading:11105342-Mitomycin,
pubmed-meshheading:11105342-Neoadjuvant Therapy,
pubmed-meshheading:11105342-Neoplasm Staging,
pubmed-meshheading:11105342-Radiotherapy Dosage,
pubmed-meshheading:11105342-Survival Analysis,
pubmed-meshheading:11105342-Treatment Outcome
|
|
pubmed:year |
2000
|
|
pubmed:articleTitle |
[Radiochemotherapy in anal canal epidermoid cancer].
|
|
pubmed:affiliation |
Centre Alexis-Vautrin, Vandoeuvre-lès-Nancy, France.
|
|
pubmed:publicationType |
Journal Article,
English Abstract,
Review
|
