| pubmed-article:11103809 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11103809 | lifeskim:mentions | umls-concept:C0027651 | lld:lifeskim |
| pubmed-article:11103809 | lifeskim:mentions | umls-concept:C1282910 | lld:lifeskim |
| pubmed-article:11103809 | lifeskim:mentions | umls-concept:C0178539 | lld:lifeskim |
| pubmed-article:11103809 | lifeskim:mentions | umls-concept:C0003316 | lld:lifeskim |
| pubmed-article:11103809 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:11103809 | lifeskim:mentions | umls-concept:C0042210 | lld:lifeskim |
| pubmed-article:11103809 | lifeskim:mentions | umls-concept:C1545588 | lld:lifeskim |
| pubmed-article:11103809 | lifeskim:mentions | umls-concept:C0063356 | lld:lifeskim |
| pubmed-article:11103809 | lifeskim:mentions | umls-concept:C1749881 | lld:lifeskim |
| pubmed-article:11103809 | lifeskim:mentions | umls-concept:C0206243 | lld:lifeskim |
| pubmed-article:11103809 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:11103809 | pubmed:issue | 22 | lld:pubmed |
| pubmed-article:11103809 | pubmed:dateCreated | 2000-12-4 | lld:pubmed |
| pubmed-article:11103809 | pubmed:abstractText | Efficient loading of MHC class II molecules with a T helper epitope of choice can be achieved through genetic exchange of the MHC class II-associated invariant chain peptide (CLIP) sequence with a sequence encoding the helper peptide. We have now used this method to engineer a cellular vaccine that continuously expresses a tumor-specific helper epitope in a defined costimulatory context. We provide evidence (a) that this cellular vaccine induces peptide-specific helper T cells in vivo that are functional in protecting mice from challenge with a highly aggressive tumor, (b) that this vaccine can directly prime tumor-specific helper T cells in vivo, and (c) that this cellular vaccine is superior compared with similar cells loaded with synthetic T helper peptide in inducing tumor protection. In conclusion, cellular vaccines for activation of antigen-specific helper T cells can be greatly improved by the introduction of invariant chain constructs containing a T helper epitope by class II-associated invariant chain peptide exchange. | lld:pubmed |
| pubmed-article:11103809 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11103809 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11103809 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11103809 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11103809 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11103809 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11103809 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11103809 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11103809 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11103809 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11103809 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11103809 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11103809 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:11103809 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:11103809 | pubmed:author | pubmed-author:MeliefC JCJ | lld:pubmed |
| pubmed-article:11103809 | pubmed:author | pubmed-author:OssendorpFF | lld:pubmed |
| pubmed-article:11103809 | pubmed:author | pubmed-author:CampsMM | lld:pubmed |
| pubmed-article:11103809 | pubmed:author | pubmed-author:OffringaRR | lld:pubmed |
| pubmed-article:11103809 | pubmed:author | pubmed-author:KoningFF | lld:pubmed |
| pubmed-article:11103809 | pubmed:author | pubmed-author:van BergenJJ | lld:pubmed |
| pubmed-article:11103809 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11103809 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:11103809 | pubmed:volume | 60 | lld:pubmed |
| pubmed-article:11103809 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11103809 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11103809 | pubmed:pagination | 6427-33 | lld:pubmed |
| pubmed-article:11103809 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:11103809 | pubmed:meshHeading | pubmed-meshheading:11103809... | lld:pubmed |
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| pubmed-article:11103809 | pubmed:meshHeading | pubmed-meshheading:11103809... | lld:pubmed |
| pubmed-article:11103809 | pubmed:meshHeading | pubmed-meshheading:11103809... | lld:pubmed |
| pubmed-article:11103809 | pubmed:meshHeading | pubmed-meshheading:11103809... | lld:pubmed |
| pubmed-article:11103809 | pubmed:meshHeading | pubmed-meshheading:11103809... | lld:pubmed |
| pubmed-article:11103809 | pubmed:meshHeading | pubmed-meshheading:11103809... | lld:pubmed |
| pubmed-article:11103809 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:11103809 | pubmed:articleTitle | Superior tumor protection induced by a cellular vaccine carrying a tumor-specific T helper epitope by genetic exchange of the class II-associated invariant chain peptide. | lld:pubmed |
| pubmed-article:11103809 | pubmed:affiliation | Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, The Netherlands. jv228@cam.ac.uk | lld:pubmed |
| pubmed-article:11103809 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11103809 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
