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rdf:type |
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lifeskim:mentions |
umls-concept:C0017337,
umls-concept:C0018284,
umls-concept:C0023467,
umls-concept:C0332466,
umls-concept:C0679058,
umls-concept:C0761476,
umls-concept:C1274040,
umls-concept:C1334913,
umls-concept:C1335268,
umls-concept:C1538631,
umls-concept:C1547699,
umls-concept:C1709390,
umls-concept:C1825005,
umls-concept:C2700640
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pubmed:issue |
22
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pubmed:dateCreated |
2000-12-4
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pubmed:databankReference |
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pubmed:abstractText |
A t(9;11)(p22;p15) chromosomal translocation was identified in an adult patient with de novo acute myelogenous leukemia. Fluorescence in situ hybridization and Southern blot analysis mapped the 11p15 break-point to the NUP98 gene. Using 3' rapid amplification of cDNA ends, we have identified a chimeric mRNA that fused the NUP98 FXFG repeats in frame to the COOH-terminal portion of the gene encoding the transcriptional coactivators p52 and p75, also known as lens epithelium-derived growth factor (LEDGF). As expected, both NUP98-p52 and NUP98-p75 (LEDGF) chimeric mRNAs were detected by reverse transcription-PCR; however, the reciprocal p52/p75 (LEDGF)-NUP98 fusion mRNA was not detected. Our results demonstrate that this is the most 5' NUP98 fusion reported and reveal a previously unrecognized genetic target, the gene encoding p52/p75 (LEDGF).
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Substances,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Pore Complex Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/PSIP1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/lens epithelium-derived growth...,
http://linkedlifedata.com/resource/pubmed/chemical/nuclear pore complex protein 98
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0008-5472
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6227-9
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:11103774-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:11103774-Amino Acid Sequence,
pubmed-meshheading:11103774-Artificial Gene Fusion,
pubmed-meshheading:11103774-Base Sequence,
pubmed-meshheading:11103774-Chromosomes, Human, Pair 11,
pubmed-meshheading:11103774-Chromosomes, Human, Pair 9,
pubmed-meshheading:11103774-Growth Substances,
pubmed-meshheading:11103774-Humans,
pubmed-meshheading:11103774-In Situ Hybridization, Fluorescence,
pubmed-meshheading:11103774-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:11103774-Leukemia, Myeloid, Acute,
pubmed-meshheading:11103774-Male,
pubmed-meshheading:11103774-Membrane Proteins,
pubmed-meshheading:11103774-Middle Aged,
pubmed-meshheading:11103774-Molecular Sequence Data,
pubmed-meshheading:11103774-Nuclear Pore Complex Proteins,
pubmed-meshheading:11103774-Nuclear Proteins,
pubmed-meshheading:11103774-RNA, Messenger,
pubmed-meshheading:11103774-Recombinant Fusion Proteins,
pubmed-meshheading:11103774-Repetitive Sequences, Nucleic Acid,
pubmed-meshheading:11103774-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:11103774-Trans-Activators,
pubmed-meshheading:11103774-Transcription Factors,
pubmed-meshheading:11103774-Translocation, Genetic
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pubmed:year |
2000
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pubmed:articleTitle |
t(9;11)(p22;p15) in acute myeloid leukemia results in a fusion between NUP98 and the gene encoding transcriptional coactivators p52 and p75-lens epithelium-derived growth factor (LEDGF).
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pubmed:affiliation |
Depurtment of Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263, USA. harisha@waushosp.org
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Case Reports,
Research Support, Non-U.S. Gov't
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