pubmed-article:11101588 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:11101588 | lifeskim:mentions | umls-concept:C0030498 | lld:lifeskim |
pubmed-article:11101588 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
pubmed-article:11101588 | lifeskim:mentions | umls-concept:C0204727 | lld:lifeskim |
pubmed-article:11101588 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
pubmed-article:11101588 | lifeskim:mentions | umls-concept:C0004572 | lld:lifeskim |
pubmed-article:11101588 | lifeskim:mentions | umls-concept:C2930674 | lld:lifeskim |
pubmed-article:11101588 | lifeskim:mentions | umls-concept:C0022341 | lld:lifeskim |
pubmed-article:11101588 | pubmed:issue | 12 | lld:pubmed |
pubmed-article:11101588 | pubmed:dateCreated | 2001-1-3 | lld:pubmed |
pubmed-article:11101588 | pubmed:abstractText | We have isolated piroplasms from a patient who developed the first case of human babesiosis in Japan by using NOD/shi-scid mice whose circulating erythrocytes (RBCs) had been replaced with human RBCs (hu-RBC-SCID mice). Following inoculation of the patient's blood specimen into hu-RBC-SCID mice, parasites proliferated within the human RBCs in the mice, resulting in a high level of parasitemia. Parasite DNA was prepared from blood samples of the patient and the mice, and the nuclear small-subunit rRNA gene (rDNA) was amplified and sequenced. Both DNA samples gave rise to identical sequences which showed the highest degree of homology (99.2%) with the Babesia microti rDNA. Because the patient had received a blood transfusion before the onset of babesiosis, we investigated the eight donors who were involved. Their archived blood samples were analyzed for specific antibody and parasite DNA; only a single donor was found to be positive by both tests, and the parasite rDNA sequence from the donor coincided with that derived from the patient. The donor's serum exhibited a high antibody titer against the isolate from the patient, whereas it exhibited only a weak cross-reaction against B. microti strains isolated in the United States. We conclude that the first Japanese babesiosis case occurred due to a blood transfusion and that the etiological agent is an indigenous Japanese parasite which may be a geographical variant of B. microti. Our results also demonstrated the usefulness of hu-RBC-SCID mice for isolation of parasites from humans and for maintenance of the parasite infectivity for human RBCs. | lld:pubmed |
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pubmed-article:11101588 | pubmed:language | eng | lld:pubmed |
pubmed-article:11101588 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11101588 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:11101588 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11101588 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:11101588 | pubmed:month | Dec | lld:pubmed |
pubmed-article:11101588 | pubmed:issn | 0095-1137 | lld:pubmed |
pubmed-article:11101588 | pubmed:author | pubmed-author:IshiharaCC | lld:pubmed |
pubmed-article:11101588 | pubmed:author | pubmed-author:TsujiMM | lld:pubmed |
pubmed-article:11101588 | pubmed:author | pubmed-author:AraiSS | lld:pubmed |
pubmed-article:11101588 | pubmed:author | pubmed-author:KamiyamaTT | lld:pubmed |
pubmed-article:11101588 | pubmed:author | pubmed-author:MatsuiTT | lld:pubmed |
pubmed-article:11101588 | pubmed:author | pubmed-author:KohsakiMM | lld:pubmed |
pubmed-article:11101588 | pubmed:author | pubmed-author:GoFF | lld:pubmed |
pubmed-article:11101588 | pubmed:author | pubmed-author:HiokiKK | lld:pubmed |
pubmed-article:11101588 | pubmed:author | pubmed-author:WeiQQ | lld:pubmed |
pubmed-article:11101588 | pubmed:author | pubmed-author:Saito-ItoAA | lld:pubmed |
pubmed-article:11101588 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:11101588 | pubmed:volume | 38 | lld:pubmed |
pubmed-article:11101588 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:11101588 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:11101588 | pubmed:pagination | 4511-6 | lld:pubmed |
pubmed-article:11101588 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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pubmed-article:11101588 | pubmed:year | 2000 | lld:pubmed |
pubmed-article:11101588 | pubmed:articleTitle | Transfusion-acquired, autochthonous human babesiosis in Japan: isolation of Babesia microti-like parasites with hu-RBC-SCID mice. | lld:pubmed |
pubmed-article:11101588 | pubmed:affiliation | Department of Medical Zoology, Kobe 650-0017, School of Veterinary Medicine, Rakuno-gakuen University, Ebetsu 069-8501, Japan. | lld:pubmed |
pubmed-article:11101588 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:11101588 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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