rdf:type |
|
lifeskim:mentions |
umls-concept:C0029341,
umls-concept:C0068781,
umls-concept:C0216660,
umls-concept:C0220781,
umls-concept:C0243077,
umls-concept:C0439849,
umls-concept:C0445223,
umls-concept:C0682744,
umls-concept:C0874161,
umls-concept:C1552599,
umls-concept:C1704787,
umls-concept:C1883254
|
pubmed:issue |
24
|
pubmed:dateCreated |
2001-1-23
|
pubmed:abstractText |
[reaction: see text] 6-Acetamido-5-amino- and -5-guanidino-3, 4-dehydro-N-(2-ethylbutyryl)-3-piperidinecarboxylic acids (8 and 9) have been synthesized starting from natural siastatin B, a bacterial neuraminidase inhibitor isolated from Streptomyces culture in a stereospecific fashion. These compounds are related to zanamivir and oseltamivir, inhibitors of influenza virus neuraminidases.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetamides,
http://linkedlifedata.com/resource/pubmed/chemical/Antiviral Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Guanidines,
http://linkedlifedata.com/resource/pubmed/chemical/Neuraminidase,
http://linkedlifedata.com/resource/pubmed/chemical/Oseltamivir,
http://linkedlifedata.com/resource/pubmed/chemical/Piperidines,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrans,
http://linkedlifedata.com/resource/pubmed/chemical/Sialic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Zanamivir,
http://linkedlifedata.com/resource/pubmed/chemical/siastatin
|
pubmed:status |
MEDLINE
|
pubmed:month |
Nov
|
pubmed:issn |
1523-7060
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pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
30
|
pubmed:volume |
2
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
3837-40
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:11101432-Acetamides,
pubmed-meshheading:11101432-Antiviral Agents,
pubmed-meshheading:11101432-Clostridium perfringens,
pubmed-meshheading:11101432-Enzyme Inhibitors,
pubmed-meshheading:11101432-Guanidines,
pubmed-meshheading:11101432-Neuraminidase,
pubmed-meshheading:11101432-Orthomyxoviridae,
pubmed-meshheading:11101432-Oseltamivir,
pubmed-meshheading:11101432-Piperidines,
pubmed-meshheading:11101432-Pyrans,
pubmed-meshheading:11101432-Sialic Acids,
pubmed-meshheading:11101432-Zanamivir
|
pubmed:year |
2000
|
pubmed:articleTitle |
Synthesis of 6-acetamido-5-amino- and -5-guanidino-3, 4-dehydro-N-(2-ethylbutyryl)- 3-piperidinecarboxylic acids related to zanamivir and oseltamivir, inhibitors of influenza virus neuraminidases.
|
pubmed:affiliation |
Institute of Microbial Chemistry, 3-14-23 Kamiosaki, Shinagawa-ku, Tokyo 141-0021, Japan.
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pubmed:publicationType |
Journal Article
|