Source:http://linkedlifedata.com/resource/pubmed/id/11100146
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
|
| pubmed:dateCreated |
2000-12-8
|
| pubmed:abstractText |
The cellular mechanisms responsible for large miniature currents in some brain synapses remain undefined. In Purkinje cells, we found that large-amplitude miniature inhibitory postsynaptic currents (mIPSCs) were inhibited by ryanodine or by long-term removal of extracellular Ca2+. Two-photon Ca2+ imaging revealed random, ryanodine-sensitive intracellular Ca2+ transients, spatially constrained at putative presynaptic terminals. At high concentration, ryanodine decreased action-potential-evoked rises in intracellular Ca2+. Immuno-localization showed ryanodine receptors in these terminals. Our data suggest that large mIPSCs are multivesicular events regulated by Ca2+ release from ryanodine-sensitive presynaptic Ca2+ stores.
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| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
1097-6256
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
3
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1256-65
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11100146-Animals,
pubmed-meshheading:11100146-Animals, Newborn,
pubmed-meshheading:11100146-Calcium,
pubmed-meshheading:11100146-Calcium Signaling,
pubmed-meshheading:11100146-Cerebellum,
pubmed-meshheading:11100146-Extracellular Space,
pubmed-meshheading:11100146-Interneurons,
pubmed-meshheading:11100146-Intracellular Fluid,
pubmed-meshheading:11100146-Kinetics,
pubmed-meshheading:11100146-Membrane Potentials,
pubmed-meshheading:11100146-Neural Inhibition,
pubmed-meshheading:11100146-Presynaptic Terminals,
pubmed-meshheading:11100146-Rats,
pubmed-meshheading:11100146-Reaction Time,
pubmed-meshheading:11100146-Ryanodine,
pubmed-meshheading:11100146-Ryanodine Receptor Calcium Release Channel,
pubmed-meshheading:11100146-Synaptic Vesicles,
pubmed-meshheading:11100146-Tetrodotoxin
|
| pubmed:year |
2000
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| pubmed:articleTitle |
Presynaptic calcium stores underlie large-amplitude miniature IPSCs and spontaneous calcium transients.
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| pubmed:affiliation |
Arbeitsgruppe Zelluläre Neurobiologie, Max-Planck-Institut für biophysikalische Chemie, 37077 Göttingen, Germany. illano@gwdg.de
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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