Linked Life Data

11099829

Source:http://linkedlifedata.com/resource/pubmed/id/11099829

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2001-2-2
pubmed:abstractText
We investigated effects of environmental estrogen-like chemicals, para-nonylphenol and bisphenol A, on hydroxy radical formation in the striatum of adult rats, using an in vivo microdialysis system. Para-nonylphenol significantly stimulated hydroxy radical formation in the striatum. Bisphenol A also increased hydroxy radical formation, albeit effect being slight. The formation of hydroxy radicals induced by para-nonylphenol was dose-dependently inhibited by tamoxifen, which suggests that the effect of this chemical was an estrogenic action via estrogen receptors. The results of the present study are the first demonstration on hydroxy radical formation induced by environmental estrogen-like chemicals and suggest that the in vivo microdialysis may be useful for evaluating toxic effects of environmental chemicals on nervous tissues.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
296
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
41-4
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Formation of hydroxy radicals by environmental estrogen-like chemicals in rat striatum.
pubmed:affiliation
Department of Pharmacology, Oita Medical University, Hasama-machi, 879-5593, Oita, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't