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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2001-2-6
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pubmed:abstractText |
The substantia nigra pars reticulata (SNR) is one of the major output nuclei of the basal ganglia. It connects the dorsal and ventral striatum with the thalamus, superior colliculus and pontomedullary brainstem. The SNR is therefore in a strategic position to regulate sensorimotor behavior. We here assessed the effects of SNR lesions on prepulse inhibition (PPI) of the acoustic startle response (ASR), stereotypy and locomotion in drug-free rats, as well as after systemic administration of the dopamine agonist DL-amphetamine (2 mg/kg), and the NMDA receptor antagonists dizocilpine (0.16 mg/kg) and CGP 40116 (2 mg/kg). SNR lesions reduced PPI, enhanced spontaneous sniffing and potentiated the locomotor stimulation by dizocilpine and CGP 40116. PPI was impaired by dizocilpine and CGP 40116 in controls. The ASR was enhanced in controls by dizocilpine and amphetamine. SNR lesions prevented the enhancement of the ASR by amphetamine. A second experiment tested the hypothesis that the SNR mediates PPI via a GABAergic inhibition of the startle pathway. Infusion of the GABA(B) antagonist phaclofen but not the GABA(A) antagonist picrotoxin into the caudal pontine reticular nucleus reduced PPI. Hence, lesion of the SNR reduces sensorimotor gating possibly by elimination of a nigroreticular GABAergic projection interacting with GABA(B) receptors. Moreover, destruction of the SNR enhances the motor stimulatory effects of amphetamine and of the NMDA antagonists dizocilpine and CGP 40116. We conclude that the SNR exerts a tonic GABAergic inhibition on sensorimotor behavior that is regulated by the dorsal and the ventral striatum.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2-Amino-5-phosphonovalerate,
http://linkedlifedata.com/resource/pubmed/chemical/2-amino-4-methyl-5-phosphono-3-pente...,
http://linkedlifedata.com/resource/pubmed/chemical/Baclofen,
http://linkedlifedata.com/resource/pubmed/chemical/Central Nervous System Stimulants,
http://linkedlifedata.com/resource/pubmed/chemical/Dextroamphetamine,
http://linkedlifedata.com/resource/pubmed/chemical/Dizocilpine Maleate,
http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/GABA Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/GABA-A Receptor Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/GABA-B Receptor Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Picrotoxin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, N-Methyl-D-Aspartate,
http://linkedlifedata.com/resource/pubmed/chemical/phaclofen
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0166-4328
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
117
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
153-62
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:11099769-2-Amino-5-phosphonovalerate,
pubmed-meshheading:11099769-Acoustic Stimulation,
pubmed-meshheading:11099769-Animals,
pubmed-meshheading:11099769-Baclofen,
pubmed-meshheading:11099769-Central Nervous System Stimulants,
pubmed-meshheading:11099769-Dextroamphetamine,
pubmed-meshheading:11099769-Dizocilpine Maleate,
pubmed-meshheading:11099769-Excitatory Amino Acid Antagonists,
pubmed-meshheading:11099769-Exploratory Behavior,
pubmed-meshheading:11099769-GABA Antagonists,
pubmed-meshheading:11099769-GABA-A Receptor Antagonists,
pubmed-meshheading:11099769-GABA-B Receptor Antagonists,
pubmed-meshheading:11099769-Male,
pubmed-meshheading:11099769-Neostriatum,
pubmed-meshheading:11099769-Picrotoxin,
pubmed-meshheading:11099769-Proactive Inhibition,
pubmed-meshheading:11099769-Rats,
pubmed-meshheading:11099769-Rats, Sprague-Dawley,
pubmed-meshheading:11099769-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:11099769-Startle Reaction,
pubmed-meshheading:11099769-Stereotyped Behavior,
pubmed-meshheading:11099769-Substantia Nigra
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pubmed:year |
2000
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pubmed:articleTitle |
Role of the substantia nigra pars reticulata in sensorimotor gating, measured by prepulse inhibition of startle in rats.
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pubmed:affiliation |
Tierphysiologie, Universität Tübingen, Auf der Morgenstelle 28, 72076, Tübingen, Germany. michael.koch@uni-bremen.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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