Source:http://linkedlifedata.com/resource/pubmed/id/11099146
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
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| pubmed:dateCreated |
2001-4-5
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| pubmed:abstractText |
This study was performed to investigate the association between human leukocyte antigen (HLA) and susceptibility to sudden sensorineural hearing loss in the Korean population. HLA-A and HLA-B typing using a standard microlymphocytotoxicity technique and HLA-DRB1 genotyping were performed in 35 patients with sudden sensorineural hearing loss and in 206 healthy controls. Prednisone (usual dose 60 mg/day) was administered for 6 days and tapered for an additional 4-6 days. Both initial hearing levels at the onset of deafness and final hearing levels after treatment were examined and evaluated for association with HLA alleles. The frequency of HLA-DRB1*14 was increased in patients with sudden sensorineural hearing loss compared with controls (relative risk [RR] = 2.7, p = 0.016). The frequencies of HLA-A2, -A31, -B52, -B61, -DRB1*04, -DRB1*11 and -DRB1*12 were slightly higher than in the controls, but did not reach statistical significance. When an association between the treatment results and HLA alleles was also evaluated, the frequency of HLA-DRB1*04 was found to be increased in the patients who did not respond to steroid treatment compared with both patients who responded well to steroid (50%, vs 16%, p = 0.034) and controls (RR = 3.0, p = 0.046). These results suggest that there is an association between HLA-DRB1*14 and disease susceptibility and that the presence of HLA-DRB1*04 may be an useful marker for predicting a poor prognosis in Korean patients with sudden sensorineural hearing loss.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-A Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-B Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DR Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DRB1 Chains,
http://linkedlifedata.com/resource/pubmed/chemical/Prednisone
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| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
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| pubmed:issn |
0001-6489
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
120
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
710-5
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:11099146-Adult,
pubmed-meshheading:11099146-Aged,
pubmed-meshheading:11099146-Anti-Inflammatory Agents,
pubmed-meshheading:11099146-Audiometry, Pure-Tone,
pubmed-meshheading:11099146-Female,
pubmed-meshheading:11099146-Gene Frequency,
pubmed-meshheading:11099146-Genetic Predisposition to Disease,
pubmed-meshheading:11099146-Genotype,
pubmed-meshheading:11099146-HLA-A Antigens,
pubmed-meshheading:11099146-HLA-B Antigens,
pubmed-meshheading:11099146-HLA-DR Antigens,
pubmed-meshheading:11099146-HLA-DRB1 Chains,
pubmed-meshheading:11099146-Hearing Loss, Sudden,
pubmed-meshheading:11099146-Humans,
pubmed-meshheading:11099146-Korea,
pubmed-meshheading:11099146-Male,
pubmed-meshheading:11099146-Middle Aged,
pubmed-meshheading:11099146-Prednisone,
pubmed-meshheading:11099146-Recovery of Function,
pubmed-meshheading:11099146-Severity of Illness Index
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| pubmed:year |
2000
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| pubmed:articleTitle |
Distribution of HLA-A, -B and -DRB1 alleles in patients with sudden sensorineural hearing loss.
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| pubmed:affiliation |
Department of Otolaryngology, Kangnam St. Mary's Hospital, The Catholic University of Korea, College of Medicine, Seoul, South Korea. swyeo@cmc.cuk.ac.kr
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|