|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
8
|
|
pubmed:dateCreated |
2001-2-9
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|
pubmed:abstractText |
A new amphiphilic, high-molecular weight poly (N-acryloylmorpholine) (PAcM) polymer has been used to be linked to oligonucleotide chains through a liquid-phase stepwise synthesis. This new conjugate has been investigated for its melting property, nuclease stability and capacity to elicit RNase H activity. Its antisense activity against an HIV-1 target has been also evaluated.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
1525-7770
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
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pubmed:volume |
19
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
1281-8
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|
pubmed:dateRevised |
2007-11-15
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|
pubmed:meshHeading |
pubmed-meshheading:11097058-Gene Expression Regulation,
pubmed-meshheading:11097058-Glucosides,
pubmed-meshheading:11097058-Inosine,
pubmed-meshheading:11097058-Molecular Structure,
pubmed-meshheading:11097058-Molecular Weight,
pubmed-meshheading:11097058-Morpholines,
pubmed-meshheading:11097058-Nucleic Acid Denaturation,
pubmed-meshheading:11097058-Oligonucleotides, Antisense,
pubmed-meshheading:11097058-Polyethylene Glycols,
pubmed-meshheading:11097058-Ribonuclease H,
pubmed-meshheading:11097058-Solubility
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|
pubmed:year |
2000
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|
pubmed:articleTitle |
PAcM-AN: poly (N-acryloylmorpholine)-conjugated antisense oligonucleotides.
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|
pubmed:affiliation |
Dept. of Chemical Sciences, University of Trieste, Italy.
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|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
