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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2000-12-21
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pubmed:databankReference |
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pubmed:abstractText |
It is well established that interferons (IFN) exert potent regulatory effects on the immune system. We have recently isolated a new IFN-induced human cDNA coding for a member of the Ring finger B-box/B30.2 subfamily that localizes to the chromosome band 11p15. We have named it Staf50. We show in this report that Staf50 is expressed in resting T cells in the absence of exogenous IFN treatment and is strongly repressed during T cell activation by anti-CD28 and anti-CD2 monoclonal antibodies (mAb) at both messenger and protein levels. In addition, we show that several members of the Ring finger B-box/B30.2 subfamily, including the 52-kDa SSA/Ro autoantigen, localize to the same chromosome band, 11p15, and are upregulated by IFN. These data led us to define a family of IFN-induced genes clustered on chromosome 11p15 that may be involved in T cell regulatory processes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD2,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD28,
http://linkedlifedata.com/resource/pubmed/chemical/Autoantigens,
http://linkedlifedata.com/resource/pubmed/chemical/Interferons,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Cytoplasmic,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ribonucleoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/SS-A antigen,
http://linkedlifedata.com/resource/pubmed/chemical/TRIM22 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/TROVE2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1079-9907
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
955-61
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pubmed:dateRevised |
2007-5-11
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pubmed:meshHeading |
pubmed-meshheading:11096452-Amino Acid Sequence,
pubmed-meshheading:11096452-Antibodies, Monoclonal,
pubmed-meshheading:11096452-Antigens, CD2,
pubmed-meshheading:11096452-Antigens, CD28,
pubmed-meshheading:11096452-Autoantigens,
pubmed-meshheading:11096452-Blotting, Northern,
pubmed-meshheading:11096452-Blotting, Western,
pubmed-meshheading:11096452-Chromosomes, Human, Pair 11,
pubmed-meshheading:11096452-Gene Expression Regulation,
pubmed-meshheading:11096452-Humans,
pubmed-meshheading:11096452-Interferons,
pubmed-meshheading:11096452-Lymphocyte Activation,
pubmed-meshheading:11096452-Molecular Sequence Data,
pubmed-meshheading:11096452-RNA, Small Cytoplasmic,
pubmed-meshheading:11096452-Repressor Proteins,
pubmed-meshheading:11096452-Ribonucleoproteins,
pubmed-meshheading:11096452-Sequence Alignment,
pubmed-meshheading:11096452-T-Lymphocytes,
pubmed-meshheading:11096452-Transcription Factors
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pubmed:year |
2000
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pubmed:articleTitle |
The interferon-inducible Staf50 gene is downregulated during T cell costimulation by CD2 and CD28.
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pubmed:affiliation |
INSERM Unité U475, 34197 Montpellier cedex 5, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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