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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
25
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pubmed:dateCreated |
2000-12-18
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pubmed:abstractText |
Although lipid peroxidation in the subendothelial space has been hypothesized to play a central role in atherogenesis, the role of vitamin E in preventing lipid peroxidation and lesion development remains uncertain. Here we show that in atherosclerosis-susceptible apolipoprotein E knockout mice, vitamin E deficiency caused by disruption of the alpha-tocopherol transfer protein gene (Ttpa) increased the severity of atherosclerotic lesions in the proximal aorta. The increase was associated with increased levels of isoprostanes, a marker of lipid peroxidation, in aortic tissue. These results show that vitamin E deficiency promotes atherosclerosis in a susceptible setting and support the hypothesis that lipid peroxidation contributes to lesion development. Ttpa(-/-) mice are a genetic model of vitamin E deficiency and should be valuable for studying other diseases in which oxidative stress is thought to play a role.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11095717-10336880,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11095717-10336881,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11095717-10364077,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11095717-10448528,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11095717-10553000,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11095717-10639540,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11095717-10748217,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11095717-13835621,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11095717-1411543,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11095717-1423598,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11095717-1584779,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11095717-2648148,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11095717-3361234,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11095717-3766953,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11095717-7495251,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11095717-7583529,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11095717-7624797,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11095717-7719340,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11095717-7738190,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11095717-7887897,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11095717-7977117,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11095717-8040256,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/11095717-9772122
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
97
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
13830-4
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:11095717-Animals,
pubmed-meshheading:11095717-Arteriosclerosis,
pubmed-meshheading:11095717-Base Sequence,
pubmed-meshheading:11095717-Carrier Proteins,
pubmed-meshheading:11095717-DNA Primers,
pubmed-meshheading:11095717-Hyperlipidemias,
pubmed-meshheading:11095717-Lipid Peroxidation,
pubmed-meshheading:11095717-Mice,
pubmed-meshheading:11095717-Mice, Inbred C57BL,
pubmed-meshheading:11095717-Mice, Knockout,
pubmed-meshheading:11095717-Vitamin E Deficiency
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pubmed:year |
2000
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pubmed:articleTitle |
Increased atherosclerosis in hyperlipidemic mice deficient in alpha -tocopherol transfer protein and vitamin E.
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pubmed:affiliation |
Gladstone Institute of Cardiovascular Disease, P. O. Box 419100, San Francisco, CA 94141-9100, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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